Publication Name	World Journal of Gastroenterology
Manuscript ID	4530
Country	China

Received	2013-07-04 09:12
Peer-Review Started	2013-07-04 14:38
To Make the First Decision	2013-07-26 18:40
Return for Revision	2013-08-05 09:29
Revised	2013-08-22 10:48
Second Decision	2013-09-16 17:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 06:31
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-09-21 18:53
Typeset the Manuscript	2013-10-19 18:28
Publish the Manuscript Online	2013-11-13 08:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Curcumin cytotoxicity is enhanced by PTEN disruption in colorectal cancer cells
Manuscript Source	Invited Manuscript
All Author List	Lin Chen, Wen-Feng Li, Hong-Xiao Wang, Hai-Na Zhao, Jia-Jia Tang, Chang-Jie Wu, Li-Ting Lu, Wan-Qin Liao and Xin-Cheng Lu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81101472 (to Liao WQ) National Natural Science Foundation of China 31071086 (to Lu XC)
Corresponding Author	Xin-Cheng Lu, Professor, Institute of Genomic Medicine, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou 325027, Zhejiang Province, China. xinchenglu@yahoo.com
Key Words	Phosphatase and tensin homolog deleted on chromosome 10; Curcumin; Chemotherapeutic agents; Cell cycle; AKT signaling
Core Tip	Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) mutations lead to cancer progression and drug resistance. Chemotherapeutic agents with enhanced effectiveness against cancers with PTEN mutations are urgently required. In this study, we generated an isogenic set of human colorectal cancer cell lines that differed only in their PTEN status. We found that curcumin showed enhanced cytotoxicity in cancer cells deficient in PTEN. Importantly, PTEN deficiency led to an alteration in the pattern of curcumin-induced cell cycle arrest, which was associated with the PTEN/AKT/p21 pathway. Our findings suggest that curcumin is a potential chemotherapeutic agent for PTEN-mutant cancers.
Publish Date	2013-11-13 08:37
Citation	Chen L, Li WF, Wang HX, Zhao HN, Tang JJ, Wu CJ, Lu LT, Liao WQ, Lu XC. Curcumin cytotoxicity is enhanced by PTEN disruption in colorectal cancer cells. World J Gastroenterol 2013; 19(40): 6814-6824
URL	http://www.wjgnet.com/1007-9327/full/v19/i40/6814.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i40.6814

Full Article (PDF)	WJG-19-6814.pdf
Manuscript File	4530-Review.doc
Answering Reviewers	4530-Answering reviewers.pdf
Copyright License Agreement	4530-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	4530-Language certificate.pdf
Peer-review Report	4530-Peer reviewer(s).pdf
Scientific Editor Work List	4530-Scientific editor work list.doc