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5/26/2019 9:49:23 AM | Browse: 862 | Download: 1645
Publication Name World Journal of Clinical Cases
Manuscript ID 45389
Country China
Received
2019-01-02 02:09
Peer-Review Started
2019-01-04 05:29
To Make the First Decision
2019-01-27 05:32
Return for Revision
2019-02-14 01:56
Revised
2019-02-19 16:18
Second Decision
2019-03-15 09:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2019-03-16 22:46
Articles in Press
2019-03-16 22:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-03-28 01:18
Typeset the Manuscript
2019-05-24 06:31
Publish the Manuscript Online
2019-05-26 09:49
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Report
Article Title Significant benefits of osimertinib in treating acquired resistance to first-generation EGFR-TKIs in squamous cell lung cancer: A case report
Manuscript Source Unsolicited Manuscript
All Author List Yan Zhang, Hui-Min Chen, Yong-Mei Liu, Feng Peng, Min Yu, Wei-Ya Wang, Heng Xu, Yong-Sheng Wang and You Lu
ORCID
Author(s) ORCID Number
Yan Zhang http://orcid.org/0000-0003-0148-7773
Hui-Min Chen http://orcid.org/0000-0003-0657-7196
Yong-Mei Liu http://orcid.org/0000-0002-0346-1158
Feng Peng http://orcid.org/0000-0003-4272-5408
Min Yu http://orcid.org/0000-0001-8978-892X
Wei-Ya Wang http://orcid.org/0000-0003-0719-6387
Heng Xu http://orcid.org/0000-0002-9549-0780
Yong-Sheng Wang http://orcid.org/0000-0002-9725-4802
You Lu http://orcid.org/0000-0003-2133-6833
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81402561
Corresponding Author Yan Zhang, PhD, Doctor, Doctor, Professor, Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. zhang.yan@gmx.com
Key Words Squamous cell lung cancer; Lung cancer; Epidermal growth factor receptor mutation; T790M; Osimertinib; Tyrosine kinase inhibitor; Targeted therapy; Case report
Core Tip This is a case report of T790M-related acquired resistant squamous cell lung cancer (SCC) patient with good response to osimertinib, which indicated T790M is also an important mechanism for acquired resistance in SCC. In this case, the secondary T790M mutation of epidermal growth factor receptor (EGFR) was detected by next-generation sequencing (NGS) for frozen tissue but not detected by ARMS-PCR for formalin-fixed and paraffin-embedded sample, which suggests NGS and better preservation conditions may contribute to higher sensitivity of EGFR T790M detection.
Publish Date 2019-05-26 09:49
Citation Zhang Y, Chen HM, Liu YM, Peng F, Yu M, Wang WY, Xu H, Wang YS, Lu Y. Significant benefits of osimertinib in treating acquired resistance to first-generation EGFR-TKIs in squamous cell lung cancer: A case report. World J Clin Cases 2019; 7(10): 1221-1229
URL https://www.wjgnet.com/2307-8960/full/v7/i10/1221.htm
DOI https://dx.doi.org/10.12998/wjcc.v7.i10.1221
Full Article (PDF) WJCC-7-1221.pdf
Full Article (Word) WJCC-7-1221.docx
Manuscript File 45389-Review_Edited.docx
Answering Reviewers 45389-Answering reviewers.pdf
Audio Core Tip 45389-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 45389-Conflict-of-interest statement.pdf
Copyright License Agreement 45389-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45389-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 45389-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 45389-Language certificate.pdf
Peer-review Report 45389-Peer-review(s).pdf
Scientific Misconduct Check 45389-Google-Gong ZM-2.png
Scientific Misconduct Check 45389-Scientific misconduct check.pdf
Scientific Editor Work List 45389-Scientific editor work list.pdf
CrossCheck Report 45389-CrossCheck report.pdf