Publication Name	World Journal of Gastroenterology
Manuscript ID	4540
Country	China

Received	2013-07-05 10:07
Peer-Review Started	2013-07-08 15:54
To Make the First Decision	2013-09-02 16:01
Return for Revision	2013-09-05 10:07
Revised	2013-10-04 08:44
Second Decision	2013-11-04 18:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-05 10:27
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-15 00:58
Typeset the Manuscript	2014-04-13 18:16
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Gastric nNOS reduction accompanied by natriuretic peptides signaling pathway upregulation in diabetic mice
Manuscript Source	Invited Manuscript
All Author List	Hong-Li Lu, Xu Huang, Yi-Song Wu, Chun-Mei Zhang, Xiang-Min Meng, Dong-Hai Liu, Young-chul Kim and Wen-Xie Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31071011 National Natural Science Foundation of China 31171107 Shanghai Natural Science Foundation 13ZR1423100
Corresponding Author	Wen-Xie Xu, Professor, Department of Physiology, Shanghai Jiaotong University School of Medicine, 800 Dongchuan Road, 328 Wenxuan Medical Building, Shanghai 200240, China. wenxiexu@sjtu.edu.cn
Key Words	Diabetic gastroparesis; Natriuretic peptides; Nitric oxide synthase; Enteric neuron
Core Tip	The results demonstrated that the expressions of neuronal nitric oxide synthase (nNOS) and numbers NOS neurons were significantly downregulated while natriuretic peptides (NPs) and the natriuretic peptide receptor-A, B, C (NPRs) signaling pathway were upregulated. C-type natriuretic peptide, an NPRs agonist, inhibited nNOS expression in cultured gastric fundus tissue. These findings suggested that upregulation of the NPs signaling pathway may be involved in gastric fundus neuropathy caused by diabetes, by decreasing nNOS expression. The results are interesting and may represent a molecular mechanism of diabetic gastroparesis.
Publish Date	2014-04-29 09:53
Citation	Lu HL, Huang X, Wu YS, Zhang CM, Meng XM, Liu DH, Kim Y, Xu WX. Gastric nNOS reduction accompanied by natriuretic peptides signaling pathway upregulation in diabetic mice. World J Gastroenterol 2014; 20(16): 4626-4635
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4626.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4626

Full Article (PDF)	WJG-20-4626.pdf
Full Article (Word)	WJG-20-4626.doc
Manuscript File	4540-Review.doc
Answering Reviewers	4540-Answering reviewers.pdf
Copyright License Agreement	4540-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4540-Language certificate.pdf
Peer-review Report	4540-Peer reviewer(s).pdf
Scientific Editor Work List	4540-Scientific editor work list.doc