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Articles Published Processes
6/14/2019 9:43:59 AM | Browse: 827 | Download: 1378
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Received |
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2019-01-02 03:24 |
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Peer-Review Started |
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2019-01-04 04:50 |
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To Make the First Decision |
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2019-03-18 06:01 |
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Return for Revision |
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2019-03-26 02:30 |
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Revised |
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2019-04-17 22:07 |
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Second Decision |
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2019-04-30 07:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-04 02:25 |
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Articles in Press |
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2019-05-04 02:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-06-13 08:04 |
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Publish the Manuscript Online |
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2019-06-14 09:43 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Eukaryotic initiation factor 5A2 and human digestive system neoplasms
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing-Bin Meng, Jing-Jing Peng, Zi-Wei Qu, Xiao-Min Zhu, Zhang Wen and Wei-Ming Kang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hubei Province |
2016CFB596 |
| Wuhan City Medical Research Project |
WX15B14 |
| Hubei Province Scientific Research Project |
WJ2015MB137 |
| Wuhan City Medical Research Project |
WX16C39 |
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| Corresponding Author |
Wei-Ming Kang, MD, Chief Doctor, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fu Yuan, Dongcheng District, Beijing 100730, China. kangweiming@163.com |
| Key Words |
Eukaryotic translation initiation factor 5A2; Hypusine modification; Acetylation modification; Drug resistance; Cancer therapeutics |
| Core Tip |
Eukaryotic initiation factor 5A2 (eIF5A2) is one of only two cellular proteins that contain the unusual amino acid hypusine. eIF5A2 initiates tumor formation, enhances cancer cell growth, increases metastasis, and promotes treatment resistance through inducing epithelial–mesenchymal transition, cytoskeletal rearrangement, angiogenesis, and metabolic reprogramming. Isoform eIF5A2 represents a promising target for treatment of human digestive system cancer. Our objective was to consolidate the current literature to better understand the expression, subcellular localization, post-translational modifications, and regulatory networks of eIF5A2, as well as its biochemical functions and evolving clinical applications in human digestive system cancer. |
| Publish Date |
2019-06-14 09:43 |
| Citation |
Meng QB, Peng JJ, Qu ZW, Zhu XM, Wen Z, Kang WM. Eukaryotic initiation factor 5A2 and human digestive system neoplasms. World J Gastrointest Oncol 2019; 11(6): 449-458 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i6/449.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i6.449 |
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