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Articles Published Processes
4/15/2019 10:50:47 AM | Browse: 684 | Download: 782
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Received |
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2019-01-02 06:10 |
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Peer-Review Started |
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2019-01-04 05:20 |
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To Make the First Decision |
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2019-01-22 02:33 |
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Return for Revision |
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2019-01-23 03:33 |
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Revised |
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2019-01-29 14:17 |
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Second Decision |
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2019-03-18 09:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-03-28 04:22 |
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Articles in Press |
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2019-03-28 04:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-04-03 19:00 |
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Typeset the Manuscript |
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2019-04-15 02:28 |
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Publish the Manuscript Online |
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2019-04-15 10:50 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medical Informatics |
| Manuscript Type |
Review |
| Article Title |
Identification of genomic features associated with immunotherapy response in gastrointestinal cancers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yin He, Zhi-Xian Liu, Ze-Hang Jiang and Xiao-Sheng Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Sheng Wang, MD, PhD, Associate Professor, Director, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China. xiaosheng.wang@cpu.edu.cn |
| Key Words |
Gastrointestinal cancer; Tumor immunity; Tumor immunotherapy; DNA mismatch repair; Tumor mutation burden; Tumor aneuploidy |
| Core Tip |
The traditional treatment strategies have a limited effect for advanced gastrointestinal (GI) cancers. Immunotherapy has shown improved effectiveness in treating diverse malignancies, including the GI cancers with mismatch repair deficiency (dMMR) or microsatellite instability (MSI). However, currently only a small subset of GI cancers can benefit from immunotherapy. Hence, it is crucial to identify predictive biomarkers for GI cancer patients responsive to immunotherapy. We reviewed the associations between three genomic features (dMMR/MSI, tumor mutation burden, and aneuploidy) and tumor immunity. These genomic features have significant correlations with anti-tumor immune response, and are useful biomarkers for immunotherapy of GI cancers. |
| Publish Date |
2019-04-15 10:50 |
| Citation |
He Y, Liu ZX, Jiang ZH, Wang XS. Identification of genomic features associated with immunotherapy response in gastrointestinal cancers. World J Gastrointest Oncol 2019; 11(4): 270-280 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i4/270.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i4.270 |
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