Publication Name	World Journal of Gastroenterology
Manuscript ID	4548
Country	China

Received	2013-07-06 10:17
Peer-Review Started	2013-07-06 18:43
To Make the First Decision	2013-08-21 18:54
Return for Revision	2013-08-27 19:36
Revised	2013-09-28 14:17
Second Decision	2013-10-21 17:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-22 06:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-06 17:33
Typeset the Manuscript	2013-11-26 10:16
Publish the Manuscript Online	2013-12-11 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Shugan-decoction relieves visceral hyperalgesia and reduces TRPV1 and SP colon expression
Manuscript Source	Invited Manuscript
All Author List	Jing-Juan Shang, Jian-Ye Yuan, Hui Xu, Rong-Zhu Tang, Yue-Bin Dong and Jian-Qun Xie
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81072786 Innovation Program of the Shanghai Municipal Education Commission 12YZ065 Longhua Medical Project D-09
Corresponding Author	Jian-Qun Xie, Professor, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai 200032, China. xiejianqun@live.cn
Key Words	Shugan-decoction; Visceral hypersensitivity; Sustained visceral hyperalgesia; Water avoidance stress; Transient receptor potential vanilloid 1; Substance P
Core Tip	The classical rat model of chronic stress induction via water avoidance stress (WAS) test was used to investigate the therapeutic effect of the Shugan-decoction (SGD) on visceral hypersensitivity of the gastrointestinal tract and its underlying molecular mechanisms. The study design reflected the therapeutic potential of SGD for treating the stress-related gut aspects of irritable bowel syndrome (IBS) in humans. Mid- and high-dose SGD treatments significantly increased the WAS-reduced pressure thresholds, similarly to those induced by the IBS drug dicetel. The SGD treatments also restored WAS-related changes in transient receptor potential vanilloid 1 and substance P expression in the colon.
Publish Date	2013-12-11 16:13
Citation	Shang JJ, Yuan JY, Xu H, Tang RZ, Dong YB, Xie JQ. Shugan-decoction relieves visceral hyperalgesia and reduces TRPV1 and SP colon expression. World J Gastroenterol 2013; 19(44): 8071-8077
URL	http://www.wjgnet.com/1007-9327/full/v19/i44/8071.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i44.8071

Full Article (PDF)	WJG-19-8071.pdf
Manuscript File	4548-Review.doc
Answering Reviewers	4548-Answering reviewers.pdf
Copyright License Agreement	4548-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4548-Language certificate.pdf
Peer-review Report	4548-Peer reviewer(s).pdf
Scientific Editor Work List	4548-Scientific editor work list.doc