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Articles Published Processes
4/25/2019 9:46:44 AM | Browse: 1155 | Download: 1273
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Received |
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2019-01-08 02:54 |
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Peer-Review Started |
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2019-01-08 07:53 |
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To Make the First Decision |
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2019-01-22 02:29 |
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Return for Revision |
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2019-01-28 00:51 |
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Revised |
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2019-03-07 13:18 |
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Second Decision |
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2019-03-15 08:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-16 16:52 |
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Articles in Press |
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2019-03-16 16:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-04-01 21:33 |
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Typeset the Manuscript |
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2019-04-25 07:20 |
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Publish the Manuscript Online |
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2019-04-25 09:46 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Application of mesenchymal stem cells therapy in the treatment of osteoarthritis of the knee: A concise review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ai-Tong Wang, Ying Feng, Hong-Hong Jia, Meng Zhao and Hao Yu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hao Yu, PhD, Doctor, Doctor, Cell Products of National Engineering Research Center, National Stem Cell Engineering Research Center, Tianjin TEDA Fourth Street, Tianda Science Park, B3. B4 Building, Tianjin 300457, China. yuhao@amcellgene.com |
| Key Words |
Osteoarthritis; Mesenchymal stem cells; Stem cell therapy; Clinical trials |
| Core Tip |
The key points include: (1) Animal studies have reported that the expanded culture of mesenchymal stem cells (MSCs) is conducive to repairing cartilage and subchondral bone and regulating the progression of secondary osteoarthritis (OA); (2) The recent studies on the treatment of OA by MSCs have come to the stage of clinical trials, and most clinical trials have achieved significant positive results with the minimal side effects; and (3) Intra-articular injection of MSCs can offer OA patients a safe and effective treatment, yet still some problems remain to be solved in the clinical application of MSC in the treatment of OA. |
| Publish Date |
2019-04-25 09:46 |
| Citation |
Wang AT, Feng Y, Jia HH, Zhao M, Yu H. Application of mesenchymal stem cells therapy in the treatment of osteoarthritis of the knee: A concise review. World J Stem Cells 2019; 11(4): 222-235 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i4/222.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i4.222 |
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