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Articles Published Processes
7/6/2019 11:29:12 AM | Browse: 933 | Download: 1116
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Received |
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2019-01-07 00:37 |
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Peer-Review Started |
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2019-01-07 09:41 |
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To Make the First Decision |
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2019-02-20 01:05 |
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Return for Revision |
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2019-02-20 01:44 |
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Revised |
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2019-04-04 02:01 |
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Second Decision |
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2019-04-30 10:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-02 17:29 |
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Articles in Press |
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2019-05-02 17:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-23 00:29 |
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Typeset the Manuscript |
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2019-07-05 09:06 |
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Publish the Manuscript Online |
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2019-07-06 11:29 |
ISSN |
2307-8960 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Medicine, Research & Experimental |
Manuscript Type |
Review |
Article Title |
Role of the brain-gut axis in gastrointestinal cancer
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Yang-Zi Di, Bo-Sheng Han, Jun-Mao Di, Wei-Yan Liu and Qiang Tang |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Qiang Tang, PhD, Chief Doctor, Doctor, Doctor, Department of General Surgery, Shiyan Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China. tang_8q@126.com |
Key Words |
Brain-gut axis; Gastrointestinal cancer; Neurotransmitters; Neuropeptides |
Core Tip |
Although studies have revealed the role of the brain-gut-axis in cancer, the bidirectional signal transmission of the brain-gut-axis remains unclear. This review summarizes current findings concerning the relationship between the brain-gut axis and gastrointestinal (GI) cancer and focuses on the significant role of the brain-gut axis in tumorigenesis and cancer progression, including tumor proliferation, invasion, apoptosis, autophagy, and metastasis. The central nervous system, sympathetic or parasympathetic nervous systems, neurotransmitters, and neuropeptides may regulate the malignant tumor phenotype in GI cancers. An insight into these mechanisms may lead to the discovery of potential prognostic markers and new targets for GI cancer therapy. |
Publish Date |
2019-07-06 11:29 |
Citation |
Di YZ, Han BS, Di JM, Liu WY, Tang Q. Role of the brain-gut axis in gastrointestinal cancer. World J Clin Cases 2019; 7(13): 1554-1570 |
URL |
https://www.wjgnet.com/2307-8960/full/v7/i13/1554.htm |
DOI |
https://dx.doi.org/10.12998/wjcc.v7.i13.1554 |
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