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Articles Published Processes
4/13/2019 6:00:06 AM | Browse: 999 | Download: 2460
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Received |
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2019-01-06 07:17 |
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Peer-Review Started |
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2019-01-07 10:31 |
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First Decision by Editorial Office Director |
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2019-02-13 23:42 |
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Return for Revision |
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2019-02-15 03:10 |
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Revised |
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2019-03-06 06:45 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-03-15 09:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-03-16 18:00 |
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Articles in Press |
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2019-03-16 18:00 |
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Edit the Manuscript by Language Editor |
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2019-03-25 14:14 |
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Typeset the Manuscript |
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2019-04-10 10:09 |
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Publish the Manuscript Online |
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2019-04-13 06:00 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Hong Xiang, Li Yang, Xing Zhang, Xiao-Hua Ma, Run-Chen Miao, Jing-Xian Gu, Yu-Nong Fu, Qing Yao, Jing-Yao Zhang, Chang Liu, Ting Lin and Kai Qu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81773128 |
| the National Natural Science Foundation of China |
81871998 |
| the Natural Science Basic Research Plan in Shaanxi Province of China |
2018JM7013 |
| the Natural Science Basic Research Plan in Shaanxi Province of China |
2017JM8039 |
| the Research Fund for Young Star of Science and Technology in Shaanxi Province |
2018KJXX-022 |
| China Postdoctoral Science Foundation |
2018M641000 |
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| Corresponding Author |
Kai Qu, MD, PhD, Professor, Research Assistant Professor, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, West Yanta Road 277, Xi'an 710061, Shaanxi Province, China. qukaixjtu@163.com |
| Key Words |
Senescence-associated genes; Hepatocellular carcinoma; Overall survival; Risk model; Asian patients |
| Core Tip |
In the present study, we identified a total of 42 senescence-associated genes (SAGs) and found seven of them were significantly downregulated in senescent cells and upregulated in HCC tissues. By using the least absolute shrinkage and selection operator, we constructed a seven-SAG signature that could predict the overall survival (OS) of hepatocellular carcinoma. This seven-SAG signature was further validated and developed in another independent dataset from The Cancer Genome Atlas project. Moreover, our risk score system showed better utility in predicting the OS than classic serum biomarker α-fetoprotein. |
| Publish Date |
2019-04-13 06:00 |
| Citation |
Xiang XH, Yang L, Zhang X, Ma XH, Miao RC, Gu JX, Fu YN, Yao Q, Zhang JY, Liu C, Lin T, Qu K. Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma. World J Gastroenterol 2019; 25(14): 1715-1728
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| URL |
https://www.wjgnet.com/1007-9327/full/v25/i14/1715.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i14.1715 |
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