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4/15/2019 10:50:47 AM | Browse: 253 | Download: 177
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 45616
Country/Territory Brazil
2019-01-11 06:25
Peer-Review Started
2019-01-11 09:03
To Make the First Decision
2019-01-28 06:13
Return for Revision
2019-01-28 09:15
2019-02-16 13:04
Second Decision
2019-02-26 08:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-02-28 04:15
Articles in Press
2019-02-28 04:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-04-15 02:27
Publish the Manuscript Online
2019-04-15 10:50
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Up-regulation of tumor necrosis factor-α pathway survival genes and of the receptor TNFR2 in gastric cancer
Manuscript Source Invited Manuscript
All Author List Ana Flávia Teixeira Rossi, Julia Cocenzo Contiero, Fernanda da Silva Manoel-Caetano, Fábio Eduardo Severino and Ana Elizabete Silva
Author(s) ORCID Number
Ana Flávia Teixeira Rossi http://orcid.org/0000-0002-3476-2885
Julia Cocenzo Contiero http://orcid.org/0000-0002-3944-2717
Fernanda da Silva Manoel-Caetano http://orcid.org/0000-0001-6717-5874
Fábio Eduardo Severino http://orcid.org/0000-0002-2304-3404
Ana Elizabete Silva http://orcid.org/0000-0003-1491-8878
Funding Agency and Grant Number
Funding Agency Grant Number
São Paulo Research Foundation-FAPESP 2015/21464-0
São Paulo Research Foundation-FAPESP 2015/23392-7
National Counsel of Technological and Scientific Development-CNPq 140723/2015-3
Corresponding author Ana Elizabete Silva, PhD, Adjunct Professor, Department of Biology, São Paulo State University – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto SP 15054-000, Brazil. ae.silva@unesp.br
Keywords Gastric cancer; Tumor necrosis factor-α signaling; TNFR1; TNFR2; Cellular survival; MicroRNAs
Core Tip We evaluated the expression of mRNA and microRNAs (miRNAs) related to the tumor necrosis factor (TNF)-α signaling pathway in gastric cancer (GC) fresh tissues. Our study shows up-regulation of cell survival genes (TNF, TNFR2, TRADD, TRAF2, CFLIP, NFKB2, CASP8) of this signaling pathway in GC, stimulating cell growth possibly by TNFR2 and negatively controls TNFR1-mediated apoptosis by down-regulation of pro-apoptotic mediators (TNFR1 and CASP3). Furthermore, interaction network between miRNAs and mRNA investigated suggests that TNF-α signaling pathway can be regulated by the action of miRNAs, mainly miR-19a and miR-103a, which may influence tumor development. Ours findings suggest TNFR2 as a potential therapeutic target for GC.
Publish Date 2019-04-15 10:50
Citation Rossi AFT, Contiero JC, Manoel-Caetano MS, Severino FE, Silva AE. Up-regulation of tumor necrosis factor-α pathway survival genes and of the receptor TNFR2 in gastric cancer. World J Gastrointest Oncol 2019; 11(4): 281-294
Url https://www.wjgnet.com/1948-5204/full/v11/i4/281.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i4.281
Full Article (PDF) WJGO-11-281.pdf
Full Article (Word) WJGO-11-281.docx
Manuscript File 45616-Review.docx
Answering Reviewers 45616-Answering reviewers.pdf
Audio Core Tip 45616-Audio core tip.mp3
Biostatistics Review Certificate 45616-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45616-Conflict-of-interest statement.pdf
Copyright License Agreement 45616-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45616-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 45616-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 45616-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 45616-Language certificate.pdf
Peer-review Report 45616-Peer-review(s).pdf
Scientific Misconduct Check 45616-Scientific misconduct check.pdf
Scientific Editor Work List 45616-Scientific editor work list.pdf