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Articles Published Processes
4/15/2019 10:50:47 AM | Browse: 1101 | Download: 1404
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Received |
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2019-01-11 06:25 |
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Peer-Review Started |
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2019-01-11 09:03 |
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To Make the First Decision |
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2019-01-28 06:13 |
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Return for Revision |
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2019-01-28 09:15 |
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Revised |
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2019-02-16 13:04 |
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Second Decision |
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2019-02-26 08:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-02-28 04:15 |
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Articles in Press |
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2019-02-28 04:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-15 02:27 |
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Publish the Manuscript Online |
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2019-04-15 10:50 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Up-regulation of tumor necrosis factor-α pathway survival genes and of the receptor TNFR2 in gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ana Flávia Teixeira Rossi, Julia Cocenzo Contiero, Fernanda da Silva Manoel-Caetano, Fábio Eduardo Severino and Ana Elizabete Silva |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation-FAPESP |
2015/21464-0 |
| São Paulo Research Foundation-FAPESP |
2015/23392-7 |
| National Counsel of Technological and Scientific Development-CNPq |
140723/2015-3 |
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| Corresponding Author |
Ana Elizabete Silva, PhD, Adjunct Professor, Department of Biology, São Paulo State University – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto SP 15054-000, Brazil. ae.silva@unesp.br |
| Key Words |
Gastric cancer; Tumor necrosis factor-α signaling; TNFR1; TNFR2; Cellular survival; MicroRNAs |
| Core Tip |
We evaluated the expression of mRNA and microRNAs (miRNAs) related to the tumor necrosis factor (TNF)-α signaling pathway in gastric cancer (GC) fresh tissues. Our study shows up-regulation of cell survival genes (TNF, TNFR2, TRADD, TRAF2, CFLIP, NFKB2, CASP8) of this signaling pathway in GC, stimulating cell growth possibly by TNFR2 and negatively controls TNFR1-mediated apoptosis by down-regulation of pro-apoptotic mediators (TNFR1 and CASP3). Furthermore, interaction network between miRNAs and mRNA investigated suggests that TNF-α signaling pathway can be regulated by the action of miRNAs, mainly miR-19a and miR-103a, which may influence tumor development. Ours findings suggest TNFR2 as a potential therapeutic target for GC. |
| Publish Date |
2019-04-15 10:50 |
| Citation |
Rossi AFT, Contiero JC, Manoel-Caetano MS, Severino FE, Silva AE. Up-regulation of tumor necrosis factor-α pathway survival genes and of the receptor TNFR2 in gastric cancer. World J Gastrointest Oncol 2019; 11(4): 281-294 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i4/281.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i4.281 |
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