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Articles Published Processes
5/6/2019 2:06:54 AM | Browse: 1168 | Download: 2904
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Received |
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2019-01-13 05:31 |
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Peer-Review Started |
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2019-01-14 07:25 |
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First Decision by Editorial Office Director |
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2019-02-13 23:03 |
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Return for Revision |
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2019-02-14 05:21 |
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Revised |
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2019-03-13 01:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-03-15 09:27 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-03-16 17:56 |
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Articles in Press |
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2019-03-16 17:56 |
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Edit the Manuscript by Language Editor |
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2019-03-28 01:23 |
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Typeset the Manuscript |
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2019-04-26 08:50 |
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Publish the Manuscript Online |
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2019-05-06 02:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Herbs-partitioned moxibustion alleviates aberrant cell apoptosis of the intestinal epithelium by upregulating A20 expression in a mouse model of Crohn’s disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Zhou, Lu-Yi Wu, Liu Chen, Ya-Jing Guo, Yi Sun, Tao Li, Ji-Meng Zhao, Chun-Hui Bao, Huan-Gan Wu and Yin Shi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
No. 81273844, 81473757 |
| the National Key Basic Research Program of China |
No.2015CB554500 |
| the Shanghai Rising-Star Program |
No.16QA1403400 |
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| Corresponding Author |
Yin Shi, PhD, Doctor, Doctor, Professor, Outpatient Department, Shanghai Institute of Acupuncture-Moxibustion and Meridian, 650 South Wanping Road, Shanghai 200030, China. flysy0636@163.com |
| Key Words |
Herbs-partitioned moxibustion; Crohn’s disease; Apoptotic pathway; Inflammation; A20 |
| Core Tip |
We report our results derived from intestinal epithelial cell A20 deletion mice in Crohn’s disease. The Crohn’s disease model was induced by 2, 4, 6 trinitrobenzene sulfonic acid. This study demonstrates for the first time that herbs-partitioned moxibustion can upregulate expression of A20, resulting in downregulation of tumor necrosis factor receptor (TNFR) 1, TNFR1-associated death domain and receptor-interacting protein 1 to alleviate increased cell apoptosis in the intestinal epithelial barrier in Crohn's disease. |
| Publish Date |
2019-05-06 02:06 |
| Citation |
Zhou J, Wu LY, Chen L, Guo YJ, Sun Y, Li T, Zhao JM, Bao CH, Wu HG and Shi Y. Herbs-partitioned moxibustion alleviates aberrant cell apoptosis of the intestinal epithelium by upregulating A20 expression in a mouse model of Crohn’s disease. World J Gastroenterol 2019; 25(17): 2071-2085
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| URL |
https://www.wjgnet.com/1007-9327/full/v25/i17/2071.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i17.2071 |
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