Publication Name	World Journal of Gastroenterology
Manuscript ID	4564
Country	India

Received	2013-07-10 08:48
Peer-Review Started	2013-07-10 09:21
To Make the First Decision	2013-07-26 18:43
Return for Revision	2013-07-29 14:21
Revised	2013-07-31 15:51
Second Decision	2013-08-06 16:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-06 23:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-08 17:39
Publish the Manuscript Online	2013-10-15 17:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Pain in chronic pancreatitis: Managing beyond the pancreatic duct
Manuscript Source	Invited Manuscript
All Author List	Rupjyoti Talukdar and D Nageshwar Reddy
Funding Agency and Grant Number
Corresponding Author	Rupjyoti Talukdar, MD, Clinical Pancreatologist, Department of Medical Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad 500082, India. rup_talukdar@yahoo.com
Key Words	Pain; Chronic pancreatitis; Nociception; Neuroplasticity; Antioxidant micronutrients; Pregabalin; Pancreatic enzymes
Core Tip	Pain in chronic pancreatitis (CP) has multiple but simultaneously occurring mechanisms. Recent data have shown expression of nociceptors and neurotrophic factors in different neural locations. The expression of these and other neural chemokines (fractalkine) have positive correlation with pain. Pain also results from global sensitization. Among the therapeutic modalities, beneficial effects have been demonstrated with methionine containing antioxidant micronutrients supplements and pregabalin. Of the pancreatic enzymes, only non-enteric coated preparations might benefit a subgroup of patients. The threshold for performing celiac neurolysis should be high in view of variable response across clinical trials.
Publish Date	2013-10-15 17:26
Citation	Talukdar R, Reddy DN. Pain in chronic pancreatitis: Managing beyond the pancreatic duct. World J Gastroenterol 2013; 19(38): 6319-6328
URL	http://www.wjgnet.com/1007-9327/full/v19/i38/6319.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i38.6319

Full Article (PDF)	WJG-19-6319.pdf
Manuscript File	4564-Review.docx
Answering Reviewers	4564-Answering reviewers.pdf
Copyright License Agreement	4564-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4564-Language certificate.pdf
Peer-review Report	4564-Peer reviews.pdf
Scientific Editor Work List	4564-Scientific editor work list.doc