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Articles Published Processes
9/21/2019 7:11:41 AM | Browse: 870 | Download: 1515
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Received |
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2019-04-26 01:27 |
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Peer-Review Started |
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2019-04-26 02:21 |
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To Make the First Decision |
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2019-05-27 00:30 |
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Return for Revision |
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2019-05-31 03:02 |
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Revised |
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2019-06-07 02:10 |
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Second Decision |
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2019-07-12 10:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-19 15:48 |
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Articles in Press |
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2019-07-19 15:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-08-05 02:19 |
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Typeset the Manuscript |
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2019-09-16 01:57 |
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Publish the Manuscript Online |
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2019-09-21 07:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Long non-coding RNA highly up-regulated in liver cancer promotes exosome secretion
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shun-Qi Cao, Hong Zheng, Bao-Cun Sun, Zheng-Lu Wang, Tao Liu, Dong-Hui Guo and Zhong-Yang Shen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Tianjin Clinical Research Center for Organ Transplantation Project |
15ZXLCSY00070 |
| The Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences |
2018PT32021 |
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| Corresponding Author |
Zhong-Yang Shen, MD, PhD, Chief Doctor, Professor, Department of Organ Transplantation, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. shen_zhongyang@126.com |
| Key Words |
Long non-coding RNA; Exosomes; Hepatocellular carcinoma; miR-372-3p; Rab11a; |
| Core Tip |
We found (1) HULC expression in serum exosomes of patients with HCC was higher than that in serum exosomes of healthy controls, and higher in liver cancer tissues than in adjacent tissues; (2) HULC expression in serum exosomes and liver cancer tissues correlated with the TNM classification, and that in tissues correlated with that in serum exosomes; (3) Increased HULC expression was associated with increased proliferation and invasion and reduced apoptosis of HCC cells; and (4) HULC repressed miR-372-3p expression, and miR-372-3p could directly bind both HULC and Rab11a. Furthermore, the HULC/ miR-372-3p /Rab11a axis promoted the secretion of exosomes from HCC cells. |
| Publish Date |
2019-09-21 07:11 |
| Citation |
Cao SQ, Zheng H, Sun BC, Wang ZL, Liu T, Guo DH, Shen ZY. Long non-coding RNA highly up-regulated in liver cancer promotes exosome secretion. World J Clin Cases 2019; 25(35): 5283-5299 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i35/5283.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i35.5283 |
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