Publication Name	World Journal of Gastroenterology
Manuscript ID	4567
Country	Cuba

Received	2013-07-11 08:16
Peer-Review Started	2013-07-12 08:38
To Make the First Decision	2013-08-08 11:25
Return for Revision	2013-08-12 20:54
Revised
Second Decision	2013-12-13 13:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-13 14:40
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-02-08 17:26
Typeset the Manuscript	2014-02-13 17:45
Publish the Manuscript Online	2014-02-26 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Autobiography
Article Title	Protective effects of D-002 on experimentally induced gastroesophageal reflux in rats
Manuscript Source	Invited Manuscript
All Author List	Zullyt Zamora, Vivian Molina, Rosa Mas, Yazmin Ravelo, Yohany Perez and Ambar Oyarzabal
Funding Agency and Grant Number
Corresponding Author	Zullyt Zamora, PhD, Department of Pharmacology, Centre of Natural Products, National Centre for Scientific Research, PO Box 6880, Cubanacan, Havana 10600, Cuba. zullyt.zamora@cnic.edu.cu
Key Words	D-002; Beeswax alcohols; Esophagitis; Gastroesophageal reflux; Oxidative stress
Core Tip	Beeswax alcohols (D-002) has gastroprotective effects in experimental and clinical studies. However, the effects of D-002 on gastroesophageal reflux (GER) have not been investigated. We demonstrated that acute oral administration of 25, 100 and 200 mg/kg D-002 decreased the esophageal lesion index, and esophageal malondialdehyde and sulfhydryl group concentrations. Only the highest dose of D-002 reduced the gastric secretion volume, but none modified the acidity. D-002 decreased esophageal lesions and esophageal concentrations of lipid peroxidation and protein oxidation markers in rats with experimental GER, without modifying gastric secretion acidity.
Publish Date	2014-02-26 11:18
Citation	Zamora Z, Molina V, Mas R, Ravelo Y, Perez Y, Oyarzabal A. Protective effects of D-002 on experimentally induced gastroesophageal reflux in rats. World J Gastroenterol 2014; 20(8): 2085-2090
URL	http://www.wjgnet.com/1007-9327/full/v20/i8/2085.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i8.2085

Full Article (PDF)	WJG-20-2085.pdf
Full Article (Word)	WJG-20-2085.doc
Manuscript File	4567-Review.doc
Answering Reviewers	4567-Answering reviewers.pdf
Copyright License Agreement	4567-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4567-Language certificate.pdf
Peer-review Report	4567-Peer reviews.pdf
Scientific Editor Work List	4567-Scientific editor work list.doc