Publication Name	World Journal of Gastroenterology
Manuscript ID	4571
Country	China

Received	2013-07-08 09:32
Peer-Review Started	2013-07-08 15:15
To Make the First Decision	2013-07-19 08:43
Return for Revision	2013-07-20 20:45
Revised	2013-10-18 20:44
Second Decision	2013-12-13 13:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-13 14:41
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-02-13 15:42
Typeset the Manuscript	2014-02-18 21:29
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	RAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population
Manuscript Source	Invited Manuscript
All Author List	Zheng-Ting Wang, Jia-Jia Hu, Rong Fan, Jie Zhou and Jie Zhong
Funding Agency and Grant Number
Corresponding Author	Jie Zhong, Professor, Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 600 Yushan Road, Shanghai 200025, China. jimmyzj64@medmail.com.cn
Key Words	Receptor for advanced glycation end product; Polymorphism; Crohn’s diseases; Susceptibility; Association study
Core Tip	The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor involved in several pathophysiological processes associated with inflammation. Therefore, we considered that RAGE gene is a candidate gene susceptible to Crohn’s disease (CD). This study is the first to investigate the association of the three most commonly studied polymorphisms in RAGE gene with CD risk in a Chinese population. The results suggest that RAGE rs1800624 and rs2070600 polymorphisms are associated with CD occurrence. The present findings support the hypothesis that a genetically impaired innate defense immunity system is a predisposing factor in the etiology of CD.
Publish Date	2014-03-06 14:13
Citation	Wang ZT, Hu JJ, Fan R, Zhou J, Zhong J. RAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population. World J Gastroenterol 2014; 20(9): 2397-2402
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2397.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2397

Full Article (PDF)	WJG-20-2397.pdf
Full Article (Word)	WJG-20-2397.doc
Manuscript File	4571-Review.doc
Answering Reviewers	4571-Answering reviewers.pdf
Copyright License Agreement	4571-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4571-Language certificate.pdf
Peer-review Report	4571-Peer reviews.pdf
Scientific Editor Work List	4571-Scientific editor work list.doc