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Articles Published Processes
4/18/2019 5:48:09 AM | Browse: 1078 | Download: 1513
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Received |
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2019-01-18 00:36 |
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Peer-Review Started |
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2019-01-18 07:47 |
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To Make the First Decision |
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2019-03-20 06:46 |
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Return for Revision |
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2019-03-21 07:01 |
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Revised |
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2019-03-21 15:57 |
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Second Decision |
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2019-03-29 10:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-30 00:46 |
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Articles in Press |
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2019-03-30 00:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-17 00:56 |
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Publish the Manuscript Online |
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2019-04-18 05:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Repurposing drugs to target nonalcoholic steatohepatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Silvia Sookoian and Carlos J Pirola |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Agencia Nacional de Promoción Científica y Tecnológica, FONCyT |
PICT 2014-0432 |
| Agencia Nacional de Promoción Científica y Tecnológica, FONCyT |
PICT 2014-1816 |
| Agencia Nacional de Promoción Científica y Tecnológica, FONCyT |
PICT 2015-0551 |
| Agencia Nacional de Promoción Científica y Tecnológica, FONCyT |
PICT 2016-0135 |
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| Corresponding Author |
Silvia Sookoian, FAASLD, MD, PhD, Senior Scientist, Department of Clinical and Molecular Hepatology, National Scientific and Technical Research Council (CONICET), University of Buenos Aires, Institute of Medical Research (IDIM), Combatientes de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina. ssookoian@intramed.net |
| Key Words |
Drug discovery; Drug repositioning; Fibrosis; Genetics; Treatment; Systems biology |
| Core Tip |
As a proof-of-concept of the advantages that can be yielded by applying multi-omics systems-based approaches to the analysis of potential candidates to the treatment of nonalcoholic steatohepatitis (NASH) we selected the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway map of nonalcoholic fatty liver disease (NAFLD), which illustrates a stage-dependent progression of the disease. After generating a protein−chemical interaction network, we predicted remarkable examples of potential drug repurposing for the treatment of NASH based on the NAFLD-KEGG connectivity map. |
| Publish Date |
2019-04-18 05:48 |
| Citation |
Sookoian S, Pirola CJ. Repurposing drugs to target nonalcoholic steatohepatitis. World J Gastroenterol 2019;25(15): 1783-1796 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i15/1783.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i15.1783 |
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