Publication Name	World Journal of Gastroenterology
Manuscript ID	4588
Country	China

Received	2013-07-10 08:48
Peer-Review Started	2013-07-10 09:25
To Make the First Decision	2013-08-08 11:25
Return for Revision	2013-08-12 21:00
Revised	2013-08-19 15:11
Second Decision	2013-09-05 11:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-05 13:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-09-12 16:15
Typeset the Manuscript	2013-10-17 15:36
Publish the Manuscript Online	2013-11-08 14:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy
Manuscript Source	Invited Manuscript
All Author List	Grace Lai-Hung Wong and Vincent Wai-Sun Wong
Funding Agency and Grant Number
Corresponding Author	Vincent WS Wong, MD, Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 9/F Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China. wongv@cuhk.edu.hk
Key Words	Antiviral therapy; Cirrhosis; Hepatitis B virus DNA; Hepatocellular carcinoma; Risk prediction score; Transient elastography
Core Tip	CU-hepatocellular carcinoma (HCC), GAG-HCC and REACH-B scores accurately predict subsequent HCC development in both treatment-na?ve patients with chronic hepatitis B and those receiving antiviral therapy. At the recommended cutoff values, baseline CU-HCC and REACH-B scores had high sensitivity, while the GAG-HCC score had high specificity in predicting HCC. Patients persistently in the low-risk category have the lowest risk of HCC; those “downgraded” in risk category have significantly lower, but a small risk of HCC compared to those in the high-risk category. Patients in the high-risk category either at baseline or after treatment should undergo HCC surveillance.
Publish Date	2013-11-08 14:06
Citation	Wong GLH, Wong VWS. Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy. World J Gastroenterol 2013; 19(39): 6515-6522
URL	http://www.wjgnet.com/1007-9327/full/v19/i39/6515.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i39.6515

Full Article (PDF)	WJG-19-6515.pdf
Manuscript File	4588-Review.docx
Answering Reviewers	4588-Answering reviewers.pdf
Copyright License Agreement	4588-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4588-Language certificate.pdf
Peer-review Report	4588-Peer reviews.pdf
Scientific Editor Work List	4588-Scientific editor work list.doc