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Articles Published Processes
6/21/2019 3:42:23 AM | Browse: 816 | Download: 1298
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Received |
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2019-01-27 02:01 |
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Peer-Review Started |
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2019-01-27 03:01 |
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To Make the First Decision |
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2019-03-20 06:34 |
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Return for Revision |
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2019-03-20 08:20 |
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Revised |
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2019-05-08 06:27 |
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Second Decision |
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2019-05-17 08:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-18 12:52 |
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Articles in Press |
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2019-05-18 12:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-24 00:57 |
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Typeset the Manuscript |
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2019-06-19 05:47 |
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Publish the Manuscript Online |
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2019-06-21 03:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Proteomics of the mediodorsal thalamic nucleus of stress-induced gastriculcer rat
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sheng-Nan Gong, Jian-Ping Zhu, Ying-Jie Ma and Dong-Qin Zhao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
No. 31501861 |
| the Natural Science Foundation of Shandong Province, China |
No. ZR2015CM013 |
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| Corresponding Author |
Dong-Qin Zhao, PhD, Associate Professor, Teacher, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Lixia District, Jinan 250014, Shandong Province, China. zhaodq@sdnu.edu.cn |
| Key Words |
Mediodorsal thalamic nucleus; Proteome; Restraint-water-immersion-stress; Stress-induced gastric ulcer; Glycogen synthase kinase-3 beta |
| Core Tip |
Quantitative proteomic analysis was used to screen for differentially expressed proteins in the mediodorsal thalamic nucleus of rats subjected to a restraint water-immersion stress state. A total of 65 dysregulated proteins were identified, which were mainly involved in the neurological disease signalling pathways. Meanwhile, the 31 upregulated proteins were primarily related to cell division, whereas the 34 downregulated proteins were related to neuron morphogenesis and neurotransmitter regulation. Furthermore, glycogen synthase kinase-3 beta might be related to the central mechanism through which restraint-water-immersion-stress gives rise to stress-induced gastric ulcer (SGU). Proteomic analysis elucidated the nervous system molecular targets of SGU. |
| Publish Date |
2019-06-21 03:42 |
| Citation |
Gong SN, Zhu JP, Ma YJ, Zhao DQ. Proteomics of the mediodorsal thalamic nucleus of stress-induced gastriculcer rat. World J Gastroenterol 2019; 25(23): 2911-2923 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i23/2911.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i23.2911 |
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