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10/22/2019 7:13:55 AM | Browse: 29 | Download: 29
Publication Name World Journal of Stem Cells
Manuscript ID 46087
Country of Manuscript Source China
Received
2019-01-29 01:48
Peer-Review Started
2019-01-29 08:11
To Make the First Decision
2019-03-18 06:32
Return for Revision
2019-03-22 01:03
Revised
2019-06-16 16:35
Second Decision
2019-05-16 07:27
Accepted by Journal Editor-in-Chief
2019-05-16 22:42
Accepted by Company Editor-in-Chief
2019-07-31 00:20
Articles in Press
2019-07-31 00:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-08-18 03:01
Typeset the Manuscript
2019-10-17 11:39
Publish the Manuscript Online
2019-10-22 07:13
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Cell Biology
Manuscript Type Basic Study
Article Title Characterization and sequencing analysis of inflammatory factor-induced changes to mesenchymal stem cell exosomes and exosomal microRNA
Manuscript Source Unsolicited Manuscript
All Author List Chen Huang, Wen-Feng Luo, Yu-Feng Ye, Li Lin, Zhe Wang, Ming-Hua Luo, Qi-De Song, Xue-Ping He, Han-Wei Chen, Yi Kong and Yu-Kuan Tang
ORCID
Author(s) ORCID Number
Chen Huang http://orcid.org/0000-0002-5707-7063
Wen-Feng Luo http://orcid.org/0000-0003-0922-1005
Yu-Feng Ye http://orcid.org/0000-0002-9843-475X
Li Lin http://orcid.org/0000-0003-3840-4265
Zhe Wang http://orcid.org/0000-0003-4220-5103
Ming-Hua Luo http://orcid.org/0000-0002-7105-9582
Qi-De Song http://orcid.org/0000-0001-5858-1205
Xue-Ping He http://orcid.org/0000-0002-6289-1115
Han-Wei Chen http://orcid.org/0000-0002-9618-542X
Yi Kong http://orcid.org/0000-0003-0348-4963
Yu-Kuan Tang http://orcid.org/0000-0002-1021-9642
Funding Agency and Grant Number
Funding Agency Grant Number
Panyu Science and Technology Plan Medical General Project 2018-Z04-47
Guangzhou Health Science and Technology Project 20191A011120
Corresponding author Yu-Kuan Tang, MD, Director, Doctor, Department of Minimally Invasive Interventional Radiology, Guangzhou Panyu Central Hospital, 8 East Fuyu Road Qiaonan Street, Panyu District, Guangzhou 511400, Guangdong Province, China. tyk20126@126.com
Keywords Mesenchymal stem cells; Exosomes; MiRNA; Inflammatory cytokines; Angiogenesis;
Core Tip The morphology and quantity of mesenchymal stem cells exosomes (MSCs-exo) are impacted in different inflammatory cytokines environment. Inflammatory cytokines impair the ability of MSCs-exo to promote angiogenesis. For instance, the tumor necrosis factor α, and interleukin 6 groups exhibited decreased numbers of angiogenesis-related microRNA (miRNA), such as miR-196a-5p, miR-17-5p, miR-146b-5p, miR-21-3p and miR-320. The same groups also downregulated angiogenesis-related signaling pathways, such as PI3K-AKT and VEGF. Inflammatory cytokines may lead to exosomal miRNAs that abnormally impact cellular components, molecular function and biological process, particularly angiogenesis-related miRNAs.
Publish Date 2019-10-22 07:13
Citation Huang C, Luo WF, Ye YF, Lin L, Wang Z, Luo MH, Song QD, He XP, Chen HW, Kong Y, Tang YK. Characterization and sequencing analysis of inflammatory factor-induced changes to mesenchymal stem cell exosomes and exosomal microRNA. World J Stem Cells 2019; 11(10):859-890
Url https://www.wjgnet.com/1948-0210/full/v11/i10/859.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i10.859
Full Article (PDF) WJSC-11-859.pdf
Full Article (Word) WJSC-11-859.docx
Manuscript File 46087-Review_Edited.doc
Answering Reviewers 46087-Answering reviewers.pdf
Audio Core Tip 46087-Audio core tip.m4a
Biostatistics Review Certificate 46087-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46087-Conflict-of-interest statement.pdf
Copyright License Agreement 46087-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46087-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 46087-Language certificate.pdf
Peer-review Report 46087-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 46087-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 46087-Scientific misconduct check.pdf
Scientific Editor Work List 46087-Scientific editor work list.pdf