| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Autobiography |
| Article Title |
ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Masataka Kudo, Ken Matsuda, Kaori Sugawara, Yuko Iki, Naotaka Kogure, Takako Saito-Ito, Kyoko Shimizu, Ikuko Sato, Takeo Yoshikawa, Akira Uruno, Ryo Ito, Atsushi Yokoyama, Akiko Saito-Hakoda, Sadayoshi Ito and Akira Sugawara |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Smoking Research Foundation |
(to Sugawara A) |
|
| Corresponding Author |
Akira Sugawara, MD, PhD, Professor, Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. akiras2i@med.tohoku.ac.jp |
| Key Words |
Angiotensin Ⅱ; Atherosclerosis; Microarray; Olmesartan; Smoking |
| Core Tip |
Tobacco smoking is well known as one of the major risk factors for coronary heart disease and nicotine is recognized as the main addictive component. We investigate the effects of nicotine and nicotine plus angiotensin Ⅱ receptor blocker (ARB) on the gene expression profile of human coronary artery endothelial cells. Nicotine induced changes in the gene expression profile related to “atherosclerosis signaling” may increase the risk for the initiation and progression of atherosclerosis. The inhibitory effect of ARB against the nicotineinduced gene expression profile may possibly induce anti-atherosclerotic effects against tobacco smoking independently of the lowering of the blood pressure. |
| Publish Date |
2014-02-25 18:31 |
| Citation |
Kudo M, Matsuda K, Sugawara K, Iki Y, Kogure N, Saito-Ito T, Shimizu K, Sato I, Yoshikawa T, Uruno A, Ito R, Yokoyama A, Saito-Hakoda A, Ito S, Sugawara A. ARB affects nicotineinduced gene expression profile in human coronary artery endothelial cells. World J Hypertens 2014; 4(1): 7-14 |
| URL |
http://www.wjgnet.com/2220-3168/full/v4/i1/7.htm |
| DOI |
http://dx.doi.org/10.5494/wjh.v4.i1.7 |
