Publication Name	World Journal of Hypertension
Manuscript ID	4617
Country	Japan

Received	2013-07-11 08:51
Peer-Review Started	2013-07-11 10:26
First Decision by Editorial Office Director
Return for Revision	2013-07-29 14:30
Revised	2013-12-12 19:45
Publication Fee Transferred
Second Decision by Editor	2014-01-16 14:25
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-16 14:40
Articles in Press
Edit the Manuscript by Language Editor	2014-02-07 19:09
Typeset the Manuscript	2014-02-23 16:13
Publish the Manuscript Online	2014-02-25 18:31

ISSN	2220-3168 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Autobiography
Article Title	ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells
Manuscript Source	Invited Manuscript
All Author List	Masataka Kudo, Ken Matsuda, Kaori Sugawara, Yuko Iki, Naotaka Kogure, Takako Saito-Ito, Kyoko Shimizu, Ikuko Sato, Takeo Yoshikawa, Akira Uruno, Ryo Ito, Atsushi Yokoyama, Akiko Saito-Hakoda, Sadayoshi Ito and Akira Sugawara
Funding Agency and Grant Number	Funding Agency Grant Number Smoking Research Foundation (to Sugawara A)
Corresponding Author	Akira Sugawara, MD, PhD, Professor, Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. akiras2i@med.tohoku.ac.jp
Key Words	Angiotensin Ⅱ; Atherosclerosis; Microarray; Olmesartan; Smoking
Core Tip	Tobacco smoking is well known as one of the major risk factors for coronary heart disease and nicotine is recognized as the main addictive component. We investigate the effects of nicotine and nicotine plus angiotensin Ⅱ receptor blocker (ARB) on the gene expression profile of human coronary artery endothelial cells. Nicotine induced changes in the gene expression profile related to “atherosclerosis signaling” may increase the risk for the initiation and progression of atherosclerosis. The inhibitory effect of ARB against the nicotineinduced gene expression profile may possibly induce anti-atherosclerotic effects against tobacco smoking independently of the lowering of the blood pressure.
Publish Date	2014-02-25 18:31
Citation	Kudo M, Matsuda K, Sugawara K, Iki Y, Kogure N, Saito-Ito T, Shimizu K, Sato I, Yoshikawa T, Uruno A, Ito R, Yokoyama A, Saito-Hakoda A, Ito S, Sugawara A. ARB affects nicotineinduced gene expression profile in human coronary artery endothelial cells. World J Hypertens 2014; 4(1): 7-14
URL	http://www.wjgnet.com/2220-3168/full/v4/i1/7.htm
DOI	http://dx.doi.org/10.5494/wjh.v4.i1.7

Full Article (PDF)	WJH-4-7.pdf
Full Article (Word)	WJH-4-7.doc
Manuscript File	4617-Review.doc
Answering Reviewers	4617-Answering reviewers.pdf
Copyright License Agreement	4617-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4617-Language certificate.pdf
Peer-review Report	4617-Peer reviews.pdf
Scientific Editor Work List	4617-Scientific editor work list.doc