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Articles Published Processes
5/28/2019 9:29:42 AM | Browse: 1019 | Download: 1660
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Received |
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2019-02-02 09:17 |
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Peer-Review Started |
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2019-02-06 09:20 |
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To Make the First Decision |
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2019-03-14 06:21 |
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Return for Revision |
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2019-03-15 03:05 |
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Revised |
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2019-03-27 23:11 |
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Second Decision |
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2019-04-19 07:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-04-20 02:04 |
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Articles in Press |
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2019-04-20 02:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-04-30 19:23 |
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Typeset the Manuscript |
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2019-05-25 07:15 |
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Publish the Manuscript Online |
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2019-05-28 09:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Hong Jiang, Zhi-Yong Zhang, Xiao-Yan Wang, Xuan Tang, Hai-Long Liu, Ai-Li Wang, Hua-Guang Li, Er-Jiang Tang and Mou-Bin Lin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81874201 |
| Shanghai Municipal Commission of Health and Family Planning |
ZK2015A32 |
| Shanghai Municipal Commission of Health and Family Planning |
201840359 |
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| Corresponding Author |
Er-Jiang Tang, MSc, Statistician, Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, No. 450 Tengyue Road, Shanghai 200090, China. tangerjiang1988051@163.com |
| Key Words |
Colorectal cancer; Lymphovascular invasion; Prognostic; DNA copy number aberration; Functional analysis |
| Core Tip |
Lymphovascular invasion (LVI) is suggested to be an obligatory step in tumor progression toward metastasis, but its genetic mechanisms in colorectal cancer (CRC) have not been fully understood. This study showed that LVI was significantly associated with features of aggressive tumors and reduced survival in CRC, and its development might correlate with inflammation, epithelial-mesenchymal transition, angiogenesis and matrix remodeling. We also constructed a DNA copy number alteration classifier that could estimate the LVI status with high accuracy, which might contribute to the management of CRC. |
| Publish Date |
2019-05-28 09:29 |
| Citation |
Jiang HH, Zhang ZY, Wang XY, Tang Y, Liu HL, Wang AL, Li HG, Tang EJ, Lin MB. Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations. World J Gastroenterol 2019; 25(20): 2489-2502 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i20/2489.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i20.2489 |
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