Publication Name	World Journal of Gastroenterology
Manuscript ID	4622
Country	China

Received	2013-07-11 09:15
Peer-Review Started	2013-07-11 10:09
To Make the First Decision	2013-08-21 18:45
Return for Revision	2013-08-23 09:26
Revised	2013-09-04 21:50
Second Decision	2013-09-17 09:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 11:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-10-10 14:07
Typeset the Manuscript	2013-12-03 08:38
Publish the Manuscript Online	2013-12-18 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Meta-Analysis
Article Title	Proton pump inhibitor for non-erosive reflux disease: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Ji-Xiang Zhang, Meng-Yao Ji, Jia Song, Hong-Bo Lei, Shi Qiu, Jing Wang, Ming-Hua Ai, Jun Wang, Xiao-Guang Lv, Zi-Rong Yang and Wei-Guo Dong
Funding Agency and Grant Number
Corresponding Author	Wei-Guo Dong, MD, PhD, Department of Gastroenterology, Renmin Hospital of Wuhan University, Ziyang Road 99, Wuhan 430060, Hubei Province, China. dwg@whu.edu.cn
Key Words	Proton pump inhibitor; Non-erosive reflux disease; Symptomatic relief; Adverse event; Meta-analysis
Core Tip	As a kind of powerful and effective acid-suppressive drugs, proton pump inhibitor (PPI) has been used for patients with non-erosive reflux disease (NERD), but its efficacy, safety and their influential factors are inconclusive. We performed this systematic review and meta-analysis of randomized controlled trials to assess its efficacy, safety and influential factors. Based on the results of the meta-analysis, we conclude that PPI has a higher symptomatic relief rate and roughly the same adverse rate for NERD. Hiatal hernia and drinking could influence symptomatic relief rate and adverse rate of PPI on NERD.
Publish Date	2013-12-18 10:39
Citation	Zhang JX, Ji MY, Song J, Lei HB, Qiu S, Wang J, Ai MH, Wang J, Lv XG, Yang ZR, Dong WG. Proton pump inhibitor for non-erosive reflux disease: A meta-analysis. World J Gastroenterol 2013; 19(45): 8408-8419
URL	http://www.wjgnet.com/1007-9327/full/v19/i45/8408.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i45.8408

Full Article (PDF)	WJG-19-8408.pdf
Manuscript File	4622-Review.doc
Answering Reviewers	4622-Answering reviewers.pdf
Copyright License Agreement	4622-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4622-Language certificate.pdf
Peer-review Report	4622-Peer reviews.pdf
Scientific Editor Work List	4622-Scientific editor work list.doc