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Articles Published Processes
3/15/2019 7:18:19 AM | Browse: 984 | Download: 1604
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Received |
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2019-02-06 03:07 |
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Peer-Review Started |
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2019-02-09 14:00 |
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To Make the First Decision |
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2019-02-20 00:33 |
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Return for Revision |
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2019-02-21 04:03 |
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Revised |
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2019-03-04 20:42 |
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Second Decision |
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2019-03-07 11:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-09 01:17 |
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Articles in Press |
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2019-03-09 01:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-03-14 09:09 |
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Publish the Manuscript Online |
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2019-03-15 07:18 |
ISSN |
1948-9358 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Retrospective Cohort Study |
Article Title |
Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Maureen M Leonard, Stephanie Camhi, Victoria Kenyon, Rebecca A Betensky, Shu Yan, Craig Sturgeon and Alessio Fasano |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Nutrition Obesity Research Center at Harvard |
P30-DK04561 |
The Harvard Clinical and Translational Science Center, the Harvard Catalyst |
NIH Award UL1 TR001102 |
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Corresponding Author |
Maureen M Leonard, MD, MSc, Instructor, Department of Pediatric Gastroenterology, Mass General Hospital for Children, 55 Fruit Street (Jackson 14), Boston, Massachusetts 02114, United States. mleonard7@partners.org |
Key Words |
Screening; Gluten; Diabetic; Coeliac; Haptoglobin; Human leukocyte antigen |
Core Tip |
Serological screening for celiac disease (CD) autoimmunity in subjects with type 1 diabetes (T1D) and their first-degree relatives (FDRs) found an underestimation of CD by 2 fold in T1D patients and 2.8 fold in their FDRs. Participants with T1D who carry DR7-DQ2/DR4-DQ8 were more likely to screen positive for CD autoimmunity. There was no association between carrying zonulin genetics and an increased risk of developing CD in our cohort. Patients with T1D and their FDRs have an increased risk of developing CD compared to the general population and, given the often-asymptomatic nature of disease, physicians should have a low threshold for screening. |
Publish Date |
2019-03-15 07:18 |
Citation |
Leonard MM, Camhi S, Kenyon V, Betensky RA, Sturgeon C, Yan S, Fasano A. Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members. World J Diabetes 2019; 10(3): 189-199 |
URL |
https://www.wjgnet.com/1948-9358/full/v10/i3/189.htm |
DOI |
https://dx.doi.org/10.4239/wjd.v10.i3.189 |
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