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Articles Published Processes
4/4/2019 3:50:15 AM | Browse: 981 | Download: 1958
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Received |
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2019-02-14 08:09 |
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Peer-Review Started |
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2019-02-17 09:50 |
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To Make the First Decision |
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2019-02-21 03:36 |
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Return for Revision |
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2019-02-22 03:29 |
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Revised |
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2019-02-23 15:50 |
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Second Decision |
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2019-03-08 08:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-12 01:37 |
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Articles in Press |
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2019-03-12 01:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-01 07:10 |
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Publish the Manuscript Online |
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2019-04-04 03:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peter Hoffmann, Cyrill Wehling, Johannes Krisam, Jan Pfeiffenberger, Nina Belling and Annika Gauss |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Annika Gauss, MD, Assistant Professor, Doctor, Doctor, Department of Gastroenterology and Hepatology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg 69120, Germany. annika.gauss@med.uni-heidelberg.de |
| Key Words |
Acute severe ulcerative colitis; Steroid-refractory; Tacrolimus; Rescue therapy; Calcineurin inhibitor; Inflammatory bowel disease; Hospitalized |
| Core Tip |
Steroid-refractory acute severe ulcerative colitis requires hospitalization and is frequently a risky tightrope walk between surgery and medical treatment. Whereas sufficient data has been provided over time to justify ciclosporin and infliximab as salvage therapies in this clinical scenario, guideline recommendations are still more reluctant towards tacrolimus due to the relative lack of data. However, tacrolimus may have advantages over ciclosporin especially due to its different toxicity profile. Our study provides more insight in the potential of tacrolimus in the strictly defined situation of steroid-refractory acute severe ulcerative colitis in hospitalized patients. |
| Publish Date |
2019-04-04 03:01 |
| Citation |
Hoffmann P, Wehling C, Krisam J, Pfeiffenberger J, Belling N, Gauss A. Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis. World J Gastroenterol 2019; 25(13): 1603-1617 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i13/1603.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i13.1603 |
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