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5/27/2019 8:24:36 AM | Browse: 781 | Download: 1188
Publication Name World Journal of Hepatology
Manuscript ID 46498
Country/Territory China
Received
2019-02-23 06:15
Peer-Review Started
2019-02-25 05:28
To Make the First Decision
2019-04-17 02:26
Return for Revision
2019-04-22 10:13
Revised
2019-05-14 01:30
Second Decision
2019-05-17 07:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-21 18:26
Articles in Press
2019-05-21 18:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-23 19:30
Typeset the Manuscript
2019-05-25 07:11
Publish the Manuscript Online
2019-05-27 08:24
ISSN 1948-5182 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Opinion Review
Article Title Roles of hepatic stellate cells in acute liver failure: From the perspective of inflammation and fibrosis
Manuscript Source Invited Manuscript
All Author List Juan Li, Ying-Ren Zhao and Zhen Tian
ORCID
Author(s) ORCID Number
Juan Li http://orcid.org/0000-0002-8246-9798
Ying-Ren Zhao http://orcid.org/0000-0001-6020-7028
Zhen Tian http://orcid.org/0000-0001-7475-9472
Funding Agency and Grant Number
Funding Agency Grant Number
China National Natural Science Foundation 81800548
Corresponding Author Zhen Tian, MD, PhD, Doctor, Department of Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Institution of Hepatology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta Road (w), Xi’an 710061, Shanxi Province, China. grace.j517@stu.xjtu.edu.cn
Key Words Acute liver failure; Hepatic stellated cells; Inflammation; Fibrosis
Core Tip Acute liver failure (ALF) is a rare life-threatening disease with a high mortality rate and characterized by massive hepatocyte death and over activation of hepatic inflammation. Hepatic stellate cells (HSCs) play both protective and promotive roles during the pathogenesis of ALF: HSCs activation participates in the maintenance of cell attachment and the architecture of liver tissue via extracellular matrix production, and assists liver regeneration by producing growth factors; HSCs inflammation plays a role in relaying inflammation signaling from sinusoids to parenchyma via secretion of inflammatory cytokines. A better understanding of roles of HSCs in ALF will lead to improvements for treating ALF patients.
Publish Date 2019-05-27 08:24
Citation Li J, Zhao YR, Tian Z. Roles of hepatic stellate cells in acute liver failure: From the perspective of inflammation and fibrosis. World J Hepatol 2019; 11(5): 412-420
URL https://www.wjgnet.com/1948-5182/full/v11/i5/412.htm
DOI https://dx.doi.org/10.4254/wjh.v11.i5.412
Full Article (PDF) WJH-11-412.pdf
Full Article (Word) WJH-11-412.docx
Manuscript File FP6862_de16_CE1RUSH_edit.docx
Answering Reviewers 46498-Answering reviewers.pdf
Audio Core Tip 46498-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 46498-Conflict-of-interest statement.pdf
Copyright License Agreement 46498-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46498-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 46498-Language certificate.pdf
Peer-review Report 46498-Peer-review(s).pdf
Scientific Misconduct Check 46498-Scientific misconduct check.pdf
Scientific Editor Work List 46498-Scientific editor work list.pdf