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Articles Published Processes
5/27/2019 8:24:36 AM | Browse: 939 | Download: 1614
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Received |
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2019-02-23 06:15 |
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Peer-Review Started |
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2019-02-25 05:28 |
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To Make the First Decision |
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2019-04-17 02:26 |
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Return for Revision |
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2019-04-22 10:13 |
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Revised |
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2019-05-14 01:30 |
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Second Decision |
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2019-05-17 07:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-21 18:26 |
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Articles in Press |
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2019-05-21 18:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-23 19:30 |
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Typeset the Manuscript |
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2019-05-25 07:11 |
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Publish the Manuscript Online |
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2019-05-27 08:24 |
| ISSN |
1948-5182 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Roles of hepatic stellate cells in acute liver failure: From the perspective of inflammation and fibrosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Juan Li, Ying-Ren Zhao and Zhen Tian |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China National Natural Science Foundation |
81800548 |
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| Corresponding Author |
Zhen Tian, MD, PhD, Doctor, Doctor, Department of Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Institution of Hepatology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta Road (w), Xi’an 710061, Shaanxi Province, China. grace.j517@stu.xjtu.edu.cn |
| Key Words |
Acute liver failure; Hepatic stellated cells; Inflammation; Fibrosis |
| Core Tip |
Acute liver failure (ALF) is a rare life-threatening disease with a high mortality rate and characterized by massive hepatocyte death and over activation of hepatic inflammation. Hepatic stellate cells (HSCs) play both protective and promotive roles during the pathogenesis of ALF: HSCs activation participates in the maintenance of cell attachment and the architecture of liver tissue via extracellular matrix production, and assists liver regeneration by producing growth factors; HSCs inflammation plays a role in relaying inflammation signaling from sinusoids to parenchyma via secretion of inflammatory cytokines. A better understanding of roles of HSCs in ALF will lead to improvements for treating ALF patients. |
| Publish Date |
2019-05-27 08:24 |
| Citation |
Li J, Zhao YR, Tian Z. Roles of hepatic stellate cells in acute liver failure: From the perspective of inflammation and fibrosis. World J Hepatol 2019; 11(5): 412-420 |
| URL |
https://www.wjgnet.com/1948-5182/full/v11/i5/412.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v11.i5.412 |
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