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Articles Published Processes
5/6/2019 2:06:54 AM | Browse: 838 | Download: 1786
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Received |
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2019-02-20 04:08 |
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Peer-Review Started |
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2019-02-20 07:26 |
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To Make the First Decision |
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2019-03-06 01:57 |
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Return for Revision |
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2019-03-06 02:16 |
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Revised |
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2019-03-17 03:24 |
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Second Decision |
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2019-03-22 08:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-25 04:30 |
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Articles in Press |
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2019-03-25 04:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-28 00:46 |
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Publish the Manuscript Online |
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2019-05-06 02:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Proton pump inhibitor: The dual role in gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Moon Kyung Joo, Jong-Jae Park and Hoon Jai Chun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program through the National Research Foundation of Korea (NRF) |
NRF-2016R1D1A1A02936964 |
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| Corresponding Author |
Moon Kyung Joo, MD, PhD, Professor, Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine Guro Hospital, 148, Gurodong-ro, Guro-gu, Seoul 08308, South Korea. latyrx@korea.ac.kr |
| Key Words |
Proton pump inhibitor; Gastric cancer; Drug resistance; Signal transducer and activator of transcription 3 |
| Core Tip |
Recent epidemiological studies have demonstrated a significant increase in gastric cancer risk following the long-term use of proton pump inhibitors (PPIs). However, observational studies have fundamental limitations. PPIs may affect gastric cancer cells and the microenvironment by modifying the acidic conditions and inhibiting the cancer stemness via various signaling pathways including signal transducer and activator of transcription 3, which in turn, reduces drug resistance to chemotherapy. In this review, we briefly summarize the current clinical outcomes of the effects of long-term PPI use and the development of gastric cancer, as well as experimental studies showing enhanced chemosensitivity in gastric cancer. |
| Publish Date |
2019-05-06 02:06 |
| Citation |
Joo MK, Park JJ, Chun HJ. Proton pump inhibitor: The dual role in gastric cancer. World J Gastroenterol 2019; 25(17): 2058-2070 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i17/2058.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i17.2058 |
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