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Articles Published Processes
8/26/2019 10:16:55 AM | Browse: 738 | Download: 1221
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Received |
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2019-02-16 14:14 |
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Peer-Review Started |
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2019-02-18 02:38 |
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To Make the First Decision |
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2019-04-16 07:30 |
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Return for Revision |
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2019-05-09 03:55 |
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Revised |
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2019-05-15 11:28 |
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Second Decision |
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2019-07-23 06:31 |
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Accepted by Journal Editor-in-Chief |
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2019-07-23 18:24 |
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Accepted by Executive Editor-in-Chief |
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2019-07-30 04:16 |
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Articles in Press |
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2019-07-30 04:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-08-22 12:26 |
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Publish the Manuscript Online |
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2019-08-26 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Derivation and applications of human hepatocyte-like cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shuang Li, Shi-Qian Huang, Yong-Xu Zhao, Yu-Jie Ding, Dan-Jun Ma and Qiu-Rong Ding |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R&D Program of China |
2017YFA0102800, 2017YFA0103700 |
| Strategic Priority Research Program of the Chinese Academy of Sciences |
XDA16030402 |
| Key Research Program of the Chinese Academy of Sciences |
ZDRW-ZS-2017-1, KFZD-SW-213 |
| National Natural Science Foundation of China |
31670829, 81600650 |
| Dongguan University of Technology Innovation Team Startup |
KCYCXPT2016003 |
| Dongguan University of Technology Faculty Star-up |
G200906-05 to D.M. |
| National Youth 1000 Talents Program |
Q.D. |
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| Corresponding Author |
Qiu-Rong Ding, PhD, Professor, CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. qrding@sibs.ac.cn |
| Key Words |
Hepatocyte-like cells; Human pluripotent stem cells; Hepatic differentiation; Biomedical application; ; |
| Core Tip |
Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells (hPSCs) have a great application prospect as an unlimited supply of human hepatocytes in disease modeling, toxicity testing and drug discovery. In this review, we summarize the derivation of HLCs from hPSCs, and the limitations and optimization of current differentiation protocols. We also discuss progress in the application of HLCs, and reveal the exciting future of HLCs for use in the study of rare diseases, population genetics, and in vitro pharmacogenomics. |
| Publish Date |
2019-08-26 10:16 |
| Citation |
Li S, Huang SQ, Zhao YX, Ding YJ, Ma DJ, Ding QR. Derivation and applications of human hepatocyte-like cells. World J Stem Cell 2019; 11(8):535-547 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i8/535.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i8.535 |
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