Publication Name	World Journal of Gastroenterology
Manuscript ID	4661
Country	South Korea

Received	2013-07-14 08:12
Peer-Review Started	2013-07-14 18:46
To Make the First Decision	2013-07-26 18:47
Return for Revision	2013-08-13 15:26
Revised	2013-09-16 16:31
Second Decision	2013-10-17 14:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-18 07:59
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-27 17:28
Typeset the Manuscript	2014-01-06 09:55
Publish the Manuscript Online	2014-01-20 17:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	Bile acid increases expression of the histamine-producing enzyme, histidine decarboxylase, in gastric cells
Manuscript Source	Invited Manuscript
All Author List	Hye Jin Ku, Hye Young Kim, Hyeong Hoe Kim, Hee Ju Park and Jae Hun Cheong
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea grant funded by the Korea government 2009-0093193
Corresponding Author	Jae Hun Cheong, PhD, Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 609-735, South Korea. molecule85@pusan.ac.kr
Key Words	Histamine; Histidine decarboxylase; Bile acid; Farnesoid X receptor
Core Tip	Histamine production and secretion in the stomach play critical roles in gastric acid secretion and in the pathogenesis of gastric diseases. Bile acids are tumor promoters, and higher levels of bile acids are found in patients with atrophic chronic gastritis and intestinal metaplasia. Increased histidine decarboxylase (HDC), which is a histamine producing enzyme, has been detected in intestinal-type gastric carcinoma. In this study, we provide new evidence that bile acids induce HDC expression in gastric cells and a series of specific transcription factors (farnesoid X receptor, small heterodimer partner, and caudal-type homeodomain transcription factor 1) play critical roles in bile acid-mediated HDC induction.
Publish Date	2014-01-20 17:10
Citation	Ku HJ, Kim HY, Kim HH, Park HJ, Cheong JH. Bile acid increases expression of the histamine-producing enzyme, histidine decarboxylase, in gastric cells. World J Gastroenterol 2014; 20(1): 175-182
URL	http://www.wjgnet.com/1007-9327/full/v20/i1/175.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i1.175

Full Article (PDF)	WJG-20-175.pdf
Full Article (Word)	WJG-20-175.doc
Manuscript File	4661-Review.doc
Answering Reviewers	4661-Answering reviewers.pdf
Copyright License Agreement	4661-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4661-Language certificate.pdf
Peer-review Report	4661-Peer reviews.pdf
Scientific Editor Work List	4661-Scientific editor work list.doc