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Articles Published Processes
8/26/2019 10:16:55 AM | Browse: 894 | Download: 1165
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Received |
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2019-03-12 06:34 |
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Peer-Review Started |
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2019-03-15 00:16 |
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To Make the First Decision |
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2019-06-05 06:49 |
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Return for Revision |
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2019-06-06 05:58 |
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Revised |
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2019-06-13 15:58 |
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Second Decision |
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2019-06-19 02:43 |
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Accepted by Journal Editor-in-Chief |
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2019-06-19 19:16 |
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Accepted by Executive Editor-in-Chief |
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2019-06-20 19:24 |
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Articles in Press |
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2019-06-20 19:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-06-29 18:35 |
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Typeset the Manuscript |
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2019-08-22 12:14 |
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Publish the Manuscript Online |
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2019-08-26 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Bone marrow microenvironment: The guardian of leukemia stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mohammad Houshmand, Teresa Mortera Blanco, Paola Circosta, Narjes Yazdi, Alireza Kazemi, Giuseppe Saglio and Mahin Nikougoftar Zarif |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mahin Nikougoftar Zarif, PhD, Associate Professor, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm 14183, Sweden. mahin.nikougoftar.zarif@ki.se |
| Key Words |
Bone marrow microenvironment; Bone marrow niche; Leukemic stem cell; Chronic myeloid leukemia; Acute myeloid leukemia; Target therapy |
| Core Tip |
Chronic myeloid leukemia stem cells (LSCs) and acute myeloid leukemia LSCs are resistant to common therapies due to the activation of downstream signaling pathways which guarantee their survival. Also, they are smart enough to escape from immune surveillance. Bone marrow microenvironment (BMM) is behind of all these phenomena by providing an environment which favor leukemia development. Recent studies confirm that targeting LSCs and their crosstalk with the BMM significantly reduces residual disease burden and eventuated in LSCs removal. |
| Publish Date |
2019-08-26 10:16 |
| Citation |
Houshmand M, Mortera Blanco T, Circosta P, Yazdi N, Kazemi A, Saglio G, Nikougoftar Zarif M. Bone marrow microenvironment: The guardian of leukemia stem cells. World J Stem cells 2019; 11(8):476-490 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i8/476.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i8.476 |
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