Publication Name	World Journal of Gastroenterology
Manuscript ID	4670
Country	China

Received	2013-07-15 11:37
Peer-Review Started	2013-07-16 10:56
To Make the First Decision	2013-07-26 18:47
Return for Revision	2013-07-29 10:03
Revised	2013-08-15 18:49
Second Decision	2013-08-20 10:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-20 13:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-26 10:00
Publish the Manuscript Online	2013-11-16 18:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Association between Ras association domain family 1A promoter methylation and hepatocellular carcinoma: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Ze-Hua Zhao, Yu-Chen Fan, Yang Yang and Kai Wang
Funding Agency and Grant Number	Funding Agency Grant Number Key Project of Chinese Ministry of Science and Technology 2012ZX10002007 Key Project of Chinese Ministry of Science and Technology 2013ZX10002001 National Natural Science Foundation of China 81171579 National Natural Science Foundation of China 81201287 Natural Science Foundation of Shandong Province, China ZR2010HM070 Natural Science Foundation of Shandong Province, China ZR2010HQ040
Corresponding Author	Kai Wang, MD, PhD, Department of Hepatology, Qilu Hospital of Shandong University, Wenhuaxi Road 107, Jinan 250012, China. wangdoc876@126.com
Key Words	Methylation; Ras association domain family 1A; Hepatocellular carcinoma; Biomarker; Diagnostic sensitivity; Diagnostic specificity
Core Tip	The published results on the diagnostic potential of Ras association domain family 1A (RASSF1A) promoter methylation for detection of hepatocellular carcinoma (HCC) are not consistent. We performed a comprehensive literature search to assess the diagnostic accuracy of RASSF1A promoter methylation. We rigorously selected patients with chronic liver diseases as controls to mimic clinical practice, and we only included studies that used body fluids as samples for detection because such an approach is non-invasive and promising for clinical application. Our meta-analysis demonstrated good sensitivity and specificity of RASSF1A methylation and may complement the ?-fetoprotein test to improve HCC detection.
Publish Date	2013-11-16 18:29
Citation	Zhao ZH, Fan YC, Yang Y, Wang K. Association between Ras association domain family 1A promoter methylation and hepatocellular carcinoma: A meta-analysis. World J Gastroenterol 2013; 19(41): 7189-7196
URL	http://www.wjgnet.com/1007-9327/full/v19/i41/7189.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i41.7189

Full Article (PDF)	WJG-19-7189.pdf
Manuscript File	4670-Review.doc
Answering Reviewers	4670-Answering reviewers.pdf
Copyright License Agreement	4670-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4670-Language certificate.pdf
Peer-review Report	4670-Peer reviews.pdf
Scientific Editor Work List	4670-Scientific editor work list.doc