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Articles Published Processes
5/28/2019 9:29:42 AM | Browse: 971 | Download: 1734
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Received |
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2019-02-21 08:10 |
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Peer-Review Started |
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2019-02-22 04:54 |
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To Make the First Decision |
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2019-03-27 03:42 |
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Return for Revision |
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2019-03-28 02:22 |
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Revised |
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2019-04-12 12:40 |
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Second Decision |
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2019-04-19 07:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-04-20 01:59 |
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Articles in Press |
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2019-04-20 01:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-05-25 07:12 |
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Publish the Manuscript Online |
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2019-05-28 09:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Changhoon Choi, Gyu Sang Yoo, Won Kyung Cho and Hee Chul Park |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hee Chul Park, MD, PhD, Full Professor, Professor, Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea. hee.ro.park@samsung.com |
| Key Words |
Hepatocellular carcinoma; Radiation therapy; Immune checkpoint inhibitors; Abscopal effect |
| Core Tip |
In the era of cancer immunotherapy, the roles of radiation therapy (RT) are not limited to the direct killing of cancerous cells but have expanded to immune modulation. Numerous proof-of-concept preclinical studies have proven that combination approaches of RT and immune checkpoint inhibitors (ICIs) are highly promising for many types of cancers, and currently, many related clinical trials are ongoing. Historically, RT was considered ineffective for hepatocellular carcinoma (HCC), but the efficacy of RT in HCC has improved greatly with technical advances. Our goal of this review is to provide a rationale for the combined treatment with RT and ICIs in HCC. |
| Publish Date |
2019-05-28 09:29 |
| Citation |
Choi C, Yoo GS, Cho WK, Park HC. Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma. World J Gastroenterol 2019; 25(20): 2416-2429 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i20/2416.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i20.2416 |
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