Publication Name	World Journal of Stem Cells
Manuscript ID	46763
Country	China

Received	2019-02-28 01:43
Peer-Review Started	2019-03-04 08:29
To Make the First Decision	2019-08-06 02:56
Return for Revision	2019-08-08 01:09
Revised	2019-08-15 18:06
Second Decision	2019-08-29 04:16
Accepted by Journal Editor-in-Chief	2019-08-30 19:15
Accepted by Company Editor-in-Chief	2019-09-05 02:49
Articles in Press	2019-09-05 02:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-12 07:21
Publish the Manuscript Online	2019-09-25 03:03

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Tendon stem/progenitor cell ageing: Modulation and rejuvenation
Manuscript Source	Invited Manuscript
All Author List	Guang-Chun Dai, Ying-Juan Li, Min-Hao Chen, Pan-Pan Lu and Yun-Feng Rui
ORCID	Author(s) ORCID Number Guang-Chun Dai http://orcid.org/0000-0003-1440-4850 Ying-Juan Li http://orcid.org/0000-0002-5580-1003 Min-Hao Chen http://orcid.org/0000-0001-9074-7076 Pan-Pan Lu http://orcid.org/0000-0002-9751-2947 Yun-Feng Rui http://orcid.org/0000-0001-9019-5531
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81871812, 81572187 National Natural Science Foundation of China for Young Scholars 81201422 Natural Science Foundation of Jiangsu Province for Young Scholars BK2012334 Summit of the Six Top Talents” Program of Jiangsu Province 2013-WSW-054 Jiangsu Provincial Medical Talent, The Project of Invigorating Health Care through Science, Technology and Education ZDRCA2016083 The Six Projects Sponsoring Talent Summits of Jiangsu Province, China LGY2017099
Corresponding Author	Yun-Feng Rui, MD, PhD, Associate Professor, Chief Doctor, Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, NO.87 Ding Jia Qiao, Nanjing 210009, Jiangsu, China. ruiyunfeng@126.com
Key Words	Tendon Stem/Progenitor Cell; Ageing; Mechanisms; Modulation; Rejuvenation;
Core Tip	Tendon stem/progenitor cells (TSPCs) play an essential role in tendon maintenance, regeneration and repair. Recent studies indicate that an association between the decreased capacities of aged TSPCs and the impaired tendon functions observed with increasing age. In this review, we briefly discuss novel updates in research investigating TSPCs characteristics. Then, we summarize the epigenetic variations in TSPCs that occur with ageing and provide a detailed description of the pathways that play essential roles in the cellular ageing process. Finally, we propose potential methods to rejuvenate ageing TSPCs and provide additional therapeutic targets for the treatment of age-related tendon diseases.
Publish Date	2019-09-25 03:03
Citation	Dai GC, Li YJ, Chen MH, Lu PP, Rui YF. Tendon stem/progenitor cell ageing: Modulation and rejuvenation. World J Stem Cells 2019; 11(9):677-692
URL	https://www.wjgnet.com/1948-0210/full/v11/i9/677.htm
DOI	https://dx.doi.org/10.4252/wjsc.v11.i9.677

Full Article (PDF)	WJSC-11-677.pdf
Full Article (Word)	WJSC-11-677.docx
Manuscript File	46763-Review.docx
Answering Reviewers	46763-Answering reviewers.pdf
Audio Core Tip	46763-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	46763-Conflict-of-interest statement.pdf
Copyright License Agreement	46763-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	46763-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	46763-Language certificate.pdf
Peer-review Report	46763-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	46763-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	46763-Scientific misconduct check.pdf
Scientific Editor Work List	46763-Scientific editor work list.pdf