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Articles Published Processes
7/6/2019 6:23:58 AM | Browse: 808 | Download: 1747
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Received |
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2019-02-23 04:18 |
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Peer-Review Started |
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2019-02-23 04:37 |
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To Make the First Decision |
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2019-04-08 00:38 |
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Return for Revision |
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2019-04-08 06:48 |
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Revised |
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2019-05-14 06:38 |
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Second Decision |
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2019-05-30 08:21 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-06-01 13:23 |
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Articles in Press |
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2019-06-01 13:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-06-10 03:18 |
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Typeset the Manuscript |
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2019-07-04 07:14 |
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Publish the Manuscript Online |
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2019-07-06 06:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sporamin suppresses the growth of xenografted colorectal carcinoma in BALB/c athymic mice by inhibiting liver β-catenin and vascular endothelial growth factor expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chun Yang, Jing-Jie Zhang, Xiao-Peng Zhang, Rong Xiao and Peng-Gao Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81573128 and 81703216 |
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| Corresponding Author |
Peng-Gao Li, PhD, Assistant Professor, School of Public Health, Capital Medical University, Beijing Key Laboratory of Clinical Epidemiology, 10 Xitoutiao, You An Men Wai, Fengtai District, Beijing 100069, China. penggao@ccmu.edu.cn |
| Key Words |
Sporamin; Colorectal cancer; Liver; Vascular endothelial growth factor; β-catenin |
| Core Tip |
Sporamin, a Kunitz-type trypsin inhibitor, restrains the growth of intraperitoneally xenografted LoVo [also known as colorectal cancer (CRC) cells] in BALB/c athymic mice. The mechanism determined by changes in morphology and tumor biomarkers in the liver involves sporamin-induced down-regulation expression of β-catenin secretion and vascular endothelial growth factor. This expression suppresses the formation of xenografted tumor nodules in vivo and subsequently inhibits the transcription of downstream genes involved in cancer progression and angiogenesis. Sporamin’s anti-cancer effects against CRCs are closely associated with its inhibitory effect on these tumor biomarkers. Further studies are warranted to elucidate the corresponding signal transduction events that mediate this process. |
| Publish Date |
2019-07-06 06:23 |
| Citation |
Yang C, Zhang JJ, Zhang XP, Xiao R, Li PG. Sporamin suppresses the growth of xenografted colorectal carcinoma in BALB/c athymic mice by inhibiting liver β-catenin and vascular endothelial growth factor expression. World J Gastroenterol 2019;25(25): 3196-3206 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i25/3196.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i25.3196 |
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