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7/6/2019 6:23:58 AM | Browse: 131 | Download: 151
Publication Name World Journal of Gastroenterology
Manuscript ID 46793
Country/Territory China
Received
2019-02-23 04:18
Peer-Review Started
2019-02-23 04:37
To Make the First Decision
2019-04-08 00:38
Return for Revision
2019-04-08 06:48
Revised
2019-05-14 06:38
Second Decision
2019-05-30 08:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-01 13:23
Articles in Press
2019-06-01 13:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-06-10 03:18
Typeset the Manuscript
2019-07-04 07:14
Publish the Manuscript Online
2019-07-06 06:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Sporamin suppresses the growth of xenografted colorectal carcinoma in BALB/c athymic mice by inhibiting liver β-catenin and vascular endothelial growth factor expression
Manuscript Source Unsolicited Manuscript
All Author List Chun Yang, Jing-Jie Zhang, Xiao-Peng Zhang, Rong Xiao and Peng-Gao Li
ORCID
Author(s) ORCID Number
Chun Yang http://orcid.org/0000-0001-9463-444X
Jing-Jie Zhang http://orcid.org/0000-0001-7261-5125
Xiao-Peng Zhang http://orcid.org/0000-0003-1389-5838
Rong Xiao http://orcid.org/0000-0002-0603-9518
Peng-Gao Li http://orcid.org/0000-0001-9134-5116
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81573128 and 81703216
Corresponding author Peng-Gao Li, PhD, Assistant Professor, School of Public Health, Capital Medical University, Beijing Key Laboratory of Clinical Epidemiology, 10 Xitoutiao, You An Men Wai, Fengtai District, Beijing 100069, China. penggao@ccmu.edu.cn
Keywords Sporamin; Colorectal cancer; Liver; Vascular endothelial growth factor; β-catenin
Core Tip Sporamin, a Kunitz-type trypsin inhibitor, restrains the growth of intraperitoneally xenografted LoVo [also known as colorectal cancer (CRC) cells] in BALB/c athymic mice. The mechanism determined by changes in morphology and tumor biomarkers in the liver involves sporamin-induced down-regulation expression of β-catenin secretion and vascular endothelial growth factor. This expression suppresses the formation of xenografted tumor nodules in vivo and subsequently inhibits the transcription of downstream genes involved in cancer progression and angiogenesis. Sporamin’s anti-cancer effects against CRCs are closely associated with its inhibitory effect on these tumor biomarkers. Further studies are warranted to elucidate the corresponding signal transduction events that mediate this process.
Publish Date 2019-07-06 06:23
Citation Yang C, Zhang JJ, Zhang XP, Xiao R, Li PG. Sporamin suppresses the growth of xenografted colorectal carcinoma in BALB/c athymic mice by inhibiting liver β-catenin and vascular endothelial growth factor expression. World J Gastroenterol 2019;25(25): 3196-3206
Url https://www.wjgnet.com/1007-9327/full/v25/i25/3196.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i25.3196
Full Article (PDF) WJG-25-3196.pdf
Full Article (Word) WJG-25-3196.docx
Manuscript File 46793-Review_Edited.docx
Answering Reviewers 46793-Answering reviewers.pdf
Audio Core Tip 46793-Audio core tip.MP3
Biostatistics Review Certificate 46793-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46793-Conflict-of-interest statement.pdf
Copyright License Agreement 46793-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46793-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 46793-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 46793-Language certificate.pdf
Peer-review Report 46793-Peer-review(s).pdf
Scientific Misconduct Check 46793-Google-MA RY-1.png
Scientific Misconduct Check 46793-Google-MA RY-2.png
Scientific Misconduct Check 46793-Scientific misconduct check.pdf
Scientific Editor Work List 46793-Scientific editor work list.pdf