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Articles Published Processes
9/25/2019 3:03:24 AM | Browse: 555 | Download: 713
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Received |
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2019-03-02 06:14 |
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Peer-Review Started |
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2019-03-04 10:57 |
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To Make the First Decision |
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2019-06-05 06:25 |
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Return for Revision |
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2019-06-27 01:40 |
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Revised |
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2019-07-07 09:02 |
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Second Decision |
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2019-08-07 00:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-08-21 05:05 |
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Articles in Press |
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2019-08-21 05:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-09-05 23:05 |
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Typeset the Manuscript |
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2019-09-12 03:23 |
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Publish the Manuscript Online |
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2019-09-25 03:03 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jian-Yun Ge, Yun-Wen Zheng, Li-Ping Liu, Hiroko Isoda and Tatsuya Oda |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81770621 |
| Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI |
16K15604, 18H02866 |
| Japan Science and Technology Agency-Japan International Cooperation Agency's (JST-JICA) Science and Technology Research Partnership for Sustainable Development (SATREPS) Project |
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| Corresponding Author |
Yun-Wen Zheng, PhD, Associate Professor, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery， Faculty of Medicine, University of Tsukuba Faculty of Medicine, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan. ywzheng@md.tsukuba.ac.jp |
| Key Words |
Chemical induction; Pluripotent reprogramming; Direct lineage conversion; Direct lineage expansion; Hepatocyte expansion; Cell fate specificity |
| Core Tip |
Chemical-mediated reprogramming is a promising strategy for generating desired cells. However, chemical-mediated pluripotent reprogramming has reproducibility difficulties, and direct lineage conversion shows significant deficiency in cell function maturation. On the other hand, direct lineage expansion from target cells not only bypasses pluripotency-related tumorigenesis but also has superior posttransplantation advantages in engraftment and functional maturation. Recent achievements in chemical expansion of human hepatocytes may help solve the cell source limitation in liver disease treatment. |
| Publish Date |
2019-09-25 03:03 |
| Citation |
Ge JY, Zheng YW, Liu LP, Isoda H, Oda T. Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes. World J Stem Cells 2019; 11(9):650-665 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i9/650.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i9.650 |
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