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Articles Published Processes
11/26/2019 1:29:07 AM | Browse: 614 | Download: 1237
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Received |
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2019-03-02 07:25 |
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Peer-Review Started |
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2019-03-04 11:04 |
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To Make the First Decision |
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2019-04-12 00:49 |
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Return for Revision |
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2019-04-24 06:57 |
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Revised |
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2019-08-13 08:40 |
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Second Decision |
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2019-10-25 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-11-05 05:05 |
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Articles in Press |
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2019-11-05 05:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-11-09 07:45 |
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Publish the Manuscript Online |
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2019-11-26 01:29 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Germline mutations in Thai patients with nonmucinous epithelial ovarian cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tarinee Manchana, Prasit Phowthongkum and Chinachote Teerapakpinyo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tarinee Manchana, MD, Associate Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, 1873, Rama IV Road, Patumwan, Bangkok 10330, Thailand. tarinee.m@chula.ac.th |
| Key Words |
BRCA mutation; Epithelial ovarian cancer; Germline mutation; Thai; ; |
| Core Tip |
Germline mutations could not be detected in any epithelial ovarian cancer patients without risk factors such as age below 40 years, significant family or personal history of cancer, and high-grade serous subtype. Mutations were detected in approximately one-third of patients with these risk factors: 25% had BRCA1/2 mutations, 5% had mutations in other homologous recombination genes, and 2.5% had MMR mutations. Significantly more germline mutations were found in patients with a family history of cancer, especially ovarian cancer. Germline BRCA mutations were detected in 38.8% of patients with the high-grade serous subtype but in only 1.6% of those with a non-high-grade serous subtype. Selected patients with the high-grade serous subtype or a significant family history of cancer should initially be considered for genetic analysis in limited resource settings. |
| Publish Date |
2019-11-26 01:29 |
| Citation |
Manchana T, Phowthongkum P, Teerapakpinyo C. Germline mutations in Thai patients with nonmucinous epithelial ovarian cancer. World J Clin Oncol 2019; 10(11): 358-368 |
| URL |
https://www.wjgnet.com/2218-4333/full/v10/i11/358.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v10.i11.358 |
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