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Articles Published Processes
9/10/2014 5:06:00 PM | Browse: 1040 | Download: 804
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Received |
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2013-07-17 09:54 |
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Peer-Review Started |
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2013-07-17 14:57 |
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To Make the First Decision |
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2013-09-02 16:28 |
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Return for Revision |
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2013-09-03 21:26 |
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Revised |
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2013-09-10 17:41 |
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Second Decision |
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2013-10-11 14:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-10-12 00:35 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-10-23 18:31 |
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Publish the Manuscript Online |
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2013-10-25 08:47 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Stephan Laggai, Yvette Simon, Theo Ranssweiler, Alexandra K Kiemer and Sonja M Kessler |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Graduiertenförderung of Saarland University |
to Laggai S |
| EASL Dame Sheila Sherlock Fellowship |
to Kessler SM |
| research committee of Saarland University |
61-cl/Anschub2012 |
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| Corresponding Author |
Alexandra K Kiemer, PhD, Professor of Pharmaceutical Biology, Department of Pharmacy, Pharmaceutical Biology, Saarland University, Campus C2.2, Saarbruecken, 66123, Germany. pharm.bio.kiemer@mx.uni-saarland.de
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| Key Words |
Non alcoholic steatohepatitis; Non alcoholic fatty liver disease; Thin layer chromatography; IMP2/IGF2BP2; p62; Methionine choline deficient diet; Polar lipids; neutral lipids; Phosphatidylcholine/phosphatidylethanolamine ratio; Triglycerides |
| Core Tip |
We describe a new method to quantify lipid classes in steatosis/steatohepatitis having advantages over both histology and classical analytical methods. Since lipid classes exert differential pathophysiological actions our method should be of interest for all researchers dealing with mechanisms of steatosis and steatohepatitis. We employ our method to investigate the lipid profile in the steatotic p62 transgenic mouse model. p62 was originally identified as an autoantigen overexpressed in hepatocellular carcinoma patients, its expression correlates with poor prognosis, and it induces steatosis. The interesting lipid profile in p62 transgenic animals suggests that it might advance the step from steatosis towards steatohepatitis. |
| Publish Date |
2013-10-25 08:47 |
| Citation |
Laggai S, Simon Y, Ranssweiler T, Kiemer AK, Kessler SM. Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH. World J Hepatol 2013; 5(10): 558-567 |
| URL |
http://www.wjgnet.com/1948-5182/full/v5/i10/558.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v5.i10.558 |
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