BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/19/2019 12:39:13 PM | Browse: 960 | Download: 1222
 |
Received |
|
2019-03-06 06:49 |
|
Peer-Review Started |
|
2019-03-06 08:26 |
|
To Make the First Decision |
|
2019-05-17 00:57 |
|
Return for Revision |
|
2019-05-20 00:50 |
|
Revised |
|
2019-05-22 16:01 |
|
Second Decision |
|
2019-05-30 08:22 |
 |
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2019-06-01 13:21 |
|
Articles in Press |
|
2019-06-01 13:21 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2019-07-17 00:27 |
|
Publish the Manuscript Online |
|
2019-07-19 12:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Alexandre Loktionov |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Alexandre Loktionov, MD, PhD, Director, Director, DiagNodus Ltd, 280, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom. alex.loktionov@diagnodus.com |
| Key Words |
Eosinophils; Eosinophilopoiesis; Gut lamina propria; Colorectal mucus; Normal human small intestine; Normal human colon; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Colorectal cancer |
| Core Tip |
Eosinophils are multifunctional granulocytes possessing readily releasable stores of cytotoxic proteins, regulatory cytokines and chemokines in their specific granules. In health eosinophils reside in the gut, exerting homeostatic functions including protective mucosal barrier integrity maintenance and contribution to gut-associated immunity. Eosinophils are important players in inflammatory bowel disease pathogenesis (both Crohn’s disease and ulcerative colitis). These cells are also associated with a favourable prognosis in colorectal cancer, however mechanisms of this association remain obscure. The author presents a comprehensive analysis of the current literature on eosinophils in the gut and highlights the importance of poorly investigated immune responses occurring within colorectal mucus. |
| Publish Date |
2019-07-19 12:39 |
| Citation |
Loktionov A. Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders. World J Gastroenterol 2019; 25(27): 3503-3526 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i27/3503.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i27.3503 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
