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Articles Published Processes
7/15/2019 10:30:02 AM | Browse: 1011 | Download: 1862
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Received |
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2019-03-14 05:34 |
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Peer-Review Started |
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2019-03-15 01:14 |
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To Make the First Decision |
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2019-04-16 06:50 |
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Return for Revision |
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2019-04-19 07:05 |
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Revised |
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2019-04-30 09:38 |
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Second Decision |
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2019-06-10 07:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-06-12 23:44 |
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Articles in Press |
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2019-06-12 23:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-07-11 18:33 |
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Typeset the Manuscript |
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2019-07-15 07:55 |
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Publish the Manuscript Online |
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2019-07-15 10:30 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anastasios Ntavatzikos, Aris Spathis, Paul Patapis, Nikolaos Machairas, Georgia Vourli, George Peros, Iordanis Papadopoulos, Ioannis Panayiotides and Anna Koumarianou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National and Kapodistrian University of Athens |
70/3/8006 |
| National and Kapodistrian University of Athens |
70/3/9114 |
| PENED - European Social Fund and Greek Ministry of Development |
70/3/8462 |
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| Corresponding Author |
Anastasios Ntavatzikos, MD, Research Scientist, Surgeon, Teacher, Hematology-Oncology Unit, 4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, Rimini 1, Haidari, Athens 12462, Greece. dmaal2@yahoo.gr |
| Key Words |
Colorectal neoplasms; Thymidylate synthase; Untranslated regions; Fluorouracil; KRAS; BRAF; Prognosis |
| Core Tip |
There is a need to identify patients with colorectal cancer (CRC) who may benefit from adjuvant chemotherapy. We investigated the survival in 130 patients with stage II-III CRC treated with adjuvant chemotherapy based on thymidylate synthase (TYMS) gene polymorphisms, KRAS and BRAF status. We found that TYMS polymorphisms and BRAF status associate independently with the survival outcomes. Prospective validating studies are required. |
| Publish Date |
2019-07-15 10:30 |
| Citation |
Ntavatzikos A, Spathis A, Patapis P, Machairas N, Vourli G, Peros G, Papadopoulos I, Panayiotides I, Koumarianou A. TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer. World J Gastrointest Oncol 2019; 551-566 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i7/551.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i7.551 |
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