BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/15/2019 10:30:02 AM | Browse: 850 | Download: 1301
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 47100
Country/Territory Greece
Received
2019-03-14 05:34
Peer-Review Started
2019-03-15 01:14
To Make the First Decision
2019-04-16 06:50
Return for Revision
2019-04-19 07:05
Revised
2019-04-30 09:38
Second Decision
2019-06-10 07:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-12 23:44
Articles in Press
2019-06-12 23:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-11 18:33
Typeset the Manuscript
2019-07-15 07:55
Publish the Manuscript Online
2019-07-15 10:30
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer
Manuscript Source Invited Manuscript
All Author List Anastasios Ntavatzikos, Aris Spathis, Paul Patapis, Nikolaos Machairas, Georgia Vourli, George Peros, Iordanis Papadopoulos, Ioannis Panayiotides and Anna Koumarianou
ORCID
Author(s) ORCID Number
Anastasios Ntavatzikos http://orcid.org/0000-0003-3343-3550
Aris Spathis http://orcid.org/0000-0001-8867-3661
Paul Patapis http://orcid.org/0000-0003-2349-769X
Nikolaos Machairas http://orcid.org/0000-0003-3239-3905
Georgia Vourli http://orcid.org/0000-0002-9727-2808
George Peros http://orcid.org/0000-0001-7401-2811
Iordanis Papadopoulos http://orcid.org/0000-0002-0620-3584
Ioannis Panayiotides http://orcid.org/0000-0002-6394-117X
Anna Koumarianou http://orcid.org/0000-0002-4159-2511
Funding Agency and Grant Number
Funding Agency Grant Number
National and Kapodistrian University of Athens 70/3/8006
National and Kapodistrian University of Athens 70/3/9114
PENED - European Social Fund and Greek Ministry of Development 70/3/8462
Corresponding Author Anastasios Ntavatzikos, MD, Research Scientist, Surgeon, Teacher, Hematology-Oncology Unit, 4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, Rimini 1, Haidari, Athens 12462, Greece. dmaal2@yahoo.gr
Key Words Colorectal neoplasms; Thymidylate synthase; Untranslated regions; Fluorouracil; KRAS; BRAF; Prognosis
Core Tip There is a need to identify patients with colorectal cancer (CRC) who may benefit from adjuvant chemotherapy. We investigated the survival in 130 patients with stage II-III CRC treated with adjuvant chemotherapy based on thymidylate synthase (TYMS) gene polymorphisms, KRAS and BRAF status. We found that TYMS polymorphisms and BRAF status associate independently with the survival outcomes. Prospective validating studies are required.
Publish Date 2019-07-15 10:30
Citation Ntavatzikos A, Spathis A, Patapis P, Machairas N, Vourli G, Peros G, Papadopoulos I, Panayiotides I, Koumarianou A. TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer. World J Gastrointest Oncol 2019; 551-566
URL https://www.wjgnet.com/1948-5204/full/v11/i7/551.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i7.551
Full Article (PDF) WJGO-11-551.pdf
Full Article (Word) WJGO-11-551.docx
Manuscript File FP6905_de26_CE1MS-edit2 20190708.docx
Answering Reviewers 47100-Answering reviewers.pdf
Audio Core Tip 47100-Audio core tip.mp3
Biostatistics Review Certificate 47100-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47100-Conflict-of-interest statement.pdf
Copyright License Agreement 47100-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47100-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 47100-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 47100-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47100-Language certificate.pdf
Peer-review Report 47100-Peer-review(s).pdf
Scientific Misconduct Check 47100-Scientific misconduct check.pdf
Scientific Editor Work List 47100-Scientific editor work list.pdf