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Articles Published Processes
10/22/2019 7:13:54 AM | Browse: 828 | Download: 1256
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Received |
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2019-03-14 02:01 |
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Peer-Review Started |
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2019-03-15 01:32 |
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To Make the First Decision |
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2019-06-05 06:50 |
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Return for Revision |
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2019-06-06 06:13 |
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Revised |
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2019-06-13 11:40 |
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Second Decision |
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2019-07-23 06:31 |
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Accepted by Journal Editor-in-Chief |
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2019-07-23 07:51 |
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Accepted by Executive Editor-in-Chief |
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2019-07-30 04:46 |
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Articles in Press |
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2019-07-30 04:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-10-14 10:19 |
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Publish the Manuscript Online |
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2019-10-22 07:13 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Genomic integrity of human induced pluripotent stem cells: Reprogramming, differentiation and applications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Clara Steichen, Zara Hannoun, Eléanor Luce, Thierry Hauet and Anne Dubart-Kupperschmitt |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Clara Steichen, PhD, Postdoctoral Fellow, INSERM U1082 IRTOMIT, CHU de Poitiers, 2 rue de la Milétrie, Poitiers F-86000, France. clara.steichen@inserm.fr |
| Key Words |
Induced pluripotent stem cells; Genomic integrity; Mutations; Karyotype; Differentiation; Cell therapy |
| Core Tip |
The potential of human induced pluripotent stem cells (hiPSCs) is no longer questioned, with applications in many fields including disease modeling and cell therapy. However, the presence of mutations in hiPSCs is a concern. After a first overview of the mutation types currently reported in hiPSCs, this review is aimed at discussing the important points to understand and possibly control the occurrence of mutations during hiPSCs reprogramming, long term culture but also differentiation. Finally, the impact of genomic alterations on the possible usages of hiPSC derivatives will be discussed, with a focus on the necessary quality controls and the potential alternatives. |
| Publish Date |
2019-10-22 07:13 |
| Citation |
Steichen C, Hannoun Z, Luce E, Hauet T, Dubart-Kupperschmitt A. Genomic integrity of human induced pluripotent stem cells: Reprogramming, differentiation and applications. World J Stem Cells 2019; 11(10):729-747 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i10/729.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i10.729 |
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