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10/22/2019 7:13:54 AM | Browse: 669 | Download: 894
Publication Name World Journal of Stem Cells
Manuscript ID 47333
Country/Territory France
Received
2019-03-14 02:01
Peer-Review Started
2019-03-15 01:32
To Make the First Decision
2019-06-05 06:50
Return for Revision
2019-06-06 06:13
Revised
2019-06-13 11:40
Second Decision
2019-07-23 06:31
Accepted by Journal Editor-in-Chief
2019-07-23 07:51
Accepted by Company Editor-in-Chief
2019-07-30 04:46
Articles in Press
2019-07-30 04:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-10-14 10:19
Publish the Manuscript Online
2019-10-22 07:13
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Genomic integrity of human induced pluripotent stem cells: Reprogramming, differentiation and applications
Manuscript Source Invited Manuscript
All Author List Clara Steichen, Zara Hannoun, Eléanor Luce, Thierry Hauet and Anne Dubart-Kupperschmitt
ORCID
Author(s) ORCID Number
Clara Steichen http://orcid.org/0000-0003-1201-4904
Zara Hannoun http://orcid.org/0000-0002-3595-8476
Eléanor Luce http://orcid.org/0000-0002-8938-8405
Thierry Hauet http://orcid.org/0000-0002-0117-071X
Anne Dubart-Kupperschmitt http://orcid.org/0000-0002-9326-4413
Funding Agency and Grant Number
Corresponding Author Clara Steichen, PhD, Postdoctoral Fellow, INSERM U1082 IRTOMIT, CHU de Poitiers, 2 rue de la Milétrie, Poitiers F-86000, France. clara.steichen@inserm.fr
Key Words Induced pluripotent stem cells; Genomic integrity; Mutations; Karyotype; Differentiation; Cell therapy
Core Tip The potential of human induced pluripotent stem cells (hiPSCs) is no longer questioned, with applications in many fields including disease modeling and cell therapy. However, the presence of mutations in hiPSCs is a concern. After a first overview of the mutation types currently reported in hiPSCs, this review is aimed at discussing the important points to understand and possibly control the occurrence of mutations during hiPSCs reprogramming, long term culture but also differentiation. Finally, the impact of genomic alterations on the possible usages of hiPSC derivatives will be discussed, with a focus on the necessary quality controls and the potential alternatives.
Publish Date 2019-10-22 07:13
Citation Steichen C, Hannoun Z, Luce E, Hauet T, Dubart-Kupperschmitt A. Genomic integrity of human induced pluripotent stem cells: Reprogramming, differentiation and applications. World J Stem Cells 2019; 11(10):729-747
URL https://www.wjgnet.com/1948-0210/full/v11/i10/729.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i10.729
Full Article (PDF) WJSC-11-729.pdf
Full Article (Word) WJSC-11-729.docx
Manuscript File 47333-Review.docx
Answering Reviewers 47333-Answering reviewers.pdf
Audio Core Tip 47333-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47333-Conflict-of-interest statement.pdf
Copyright License Agreement 47333-Copyright license agreement.pdf
Peer-review Report 47333-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 47333-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 47333-Scientific misconduct check.pdf
Scientific Editor Work List 47333-Scientific editor work list.pdf