Publication Name	World Journal of Clinical Cases
Manuscript ID	47346
Country	United States

Received	2019-03-19 01:37
Peer-Review Started	2019-03-19 14:26
To Make the First Decision	2019-09-16 03:58
Return for Revision	2019-09-18 06:06
Revised	2019-09-28 19:38
Second Decision	2019-10-14 09:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-10-15 05:28
Articles in Press	2019-10-15 05:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-10-18 00:58
Typeset the Manuscript	2019-10-23 10:39
Publish the Manuscript Online	2019-10-26 03:14

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Opinion Review
Article Title	Clinical use of low-dose aspirin for elders and sensitive subjects
Manuscript Source	Invited Manuscript
All Author List	Yan Zhang, Xiang-Ming Fang and Guo-Xun Chen
ORCID	Author(s) ORCID Number Yan Zhang http://orcid.org/0000-0002-0620-5803 Xiang-Ming Fang http://orcid.org/0000-0002-8435-6009 Guo-Xun Chen http://orcid.org/0000-0001-6226-4050
Funding Agency and Grant Number
Corresponding Author	Guo-Xun Chen, PhD, Associate Professor, Research Scientist, Department of Nutrition, The University of Tennessee, Knoxville 37909, Tennessee, The United State of America, Tennessee, Knoxville 37909, United States. gchen6@utk.edu
Key Words	Low-dose aspirin; Gastrointestinal damages; Upper gastrointestinal bleeding; Human subjects; Chinese elders;
Core Tip	Low-dose aspirin (LDA) has been used widely for prevention of cardiovascular and cerebrovascular diseases. This is attributed to the role of aspirin in the inhibition of cyclooxygenases to prevent or reduce thrombosis. However, the use of LDA has been associated with gastrointestinal injuries such as ulcer and bleeding in sensitive human subjects. This opinion review summarized recent Chinese publications showing gastrointestinal damages in Chinese elders using LDA. It tries to argue that cautions should be taken when LDA is recommended, and alternative means should be considered for those elderly and sensitive subjects in China.
Publish Date	2019-10-26 03:14
Citation	Zhang Y, Fang XM, Chen GX. Clinical use of low-dose aspirin for elders and sensitive subjects. World J Clin Cases 2019; 7(20): 3168-3174
URL	https://www.wjgnet.com/2307-8960/full/v7/i20/3168.htm
DOI	https://dx.doi.org/10.12998/wjcc.v7.i20.3168

Full Article (PDF)	WJCC-7-3168.pdf
Full Article (Word)	WJCC-7-3168.docx
Manuscript File	FP7058_ce5_CE1MS-edit2.docx
Answering Reviewers	47346-Answering reviewers.pdf
Audio Core Tip	47346-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	47346-Conflict-of-interest statement.pdf
Copyright License Agreement	47346-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	47346-Language certificate.pdf
Peer-review Report	47346-Peer-review(s).pdf
Scientific Misconduct Check	47346-Scientific misconduct check.pdf
Scientific Editor Work List	47346-Scientific editor work list.pdf
CrossCheck Report	47346-CrossCheck report.pdf