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Articles Published Processes
6/21/2019 3:42:23 AM | Browse: 992 | Download: 1601
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Received |
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2019-03-20 01:46 |
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Peer-Review Started |
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2019-03-20 06:47 |
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To Make the First Decision |
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2019-04-08 00:44 |
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Return for Revision |
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2019-04-08 07:11 |
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Revised |
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2019-04-26 08:16 |
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Second Decision |
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2019-05-08 08:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-08 16:06 |
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Articles in Press |
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2019-05-08 16:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-06-19 03:53 |
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Publish the Manuscript Online |
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2019-06-21 03:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alaattin Sen and Holger Stark |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Alaattin Sen, PhD, Academic Fellow, Academic Research, Chairman, Full Professor, Instructor, Professor, Research Scientist, Senior Lecturer, Senior Researcher, Senior Scientist, Department of Molecular Biology and Genetics, Faculty of Life and Natural Sciences, Abdullah Gul University, Sumer Campus, Kocasinan, Kayseri 38080, Türkiye. sena@agu.edu.tr |
| Key Words |
Cytochrome P450; Polymorphism; Function; Ulcerative colitis; Aetiology |
| Core Tip |
The role of cytochrome P450s (CYPs) genes in the pathogenesis of ulcerative colitis (UC). Extrahepatic and extrarenal CYPs (e.g., macrophages and dendritic cells of colonic mucosa) have a critical role in UC development. Polymorphisms discussed can result in dysregulation of these enzymes in favour of alternative pathways producing more reactive metabolites. Production of reactive metabolites is favouring more severe disease states. Pharmacogenetics might facilitate individualized medicine for UC in the future although actually available data is limited. |
| Publish Date |
2019-06-21 03:42 |
| Citation |
Sen A, Stark H. Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis. World J Gastroenterol 2019; 25(23): 2846-2862 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i23/2846.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i23.2846 |
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