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Articles Published Processes
7/6/2019 6:23:58 AM | Browse: 763 | Download: 1207
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Received |
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2019-03-15 03:06 |
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Peer-Review Started |
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2019-03-15 06:18 |
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To Make the First Decision |
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2019-04-11 08:25 |
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Return for Revision |
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2019-04-12 00:46 |
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Revised |
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2019-04-25 16:55 |
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Second Decision |
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2019-05-17 09:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-18 12:45 |
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Articles in Press |
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2019-05-18 12:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-07-04 07:11 |
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Publish the Manuscript Online |
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2019-07-06 06:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Revisiting the liver’s role in transplant alloimmunity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nitin Abrol, Caroline C Jadlowiec and Timucin Taner |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Timucin Taner, FACS, MD, PhD, Associate Professor, Surgeon, William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, United States. taner.timucin@mayo.edu |
| Key Words |
Liver transplantation; Alloimmunity; Liver-kidney transplant; Tolerance; Rejection |
| Core Tip |
The liver not only protects itself from host alloimmune responses, but also modulates alloimmune responses to other simultaneously transplanted solid organs like heart or kidney. The titer of donor specific alloantibodies decreases after liver transplantation, making transplantation of other solid organs possible even in highly sensitized high-risk patients. The immune cells from the liver allograft cross-talk with recipient immune cells and modulate the immune system towards tolerance. The cross-talk between these cells suppress the genes involved in alloimmunity and upregulate the genes involved in tissue repair and metabolism. |
| Publish Date |
2019-07-06 06:23 |
| Citation |
Abrol N, Jadlowiec CC, Taner T. Revisiting liver’s role in transplant alloimmunity. World J Gastroenterol 2019; 25(25): 3123-3135 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i25/3123.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i25.3123 |
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