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7/14/2019 11:25:18 AM | Browse: 67 | Download: 87
Publication Name World Journal of Gastroenterology
Manuscript ID 47414
Country of Manuscript Source China
Received
2019-03-14 00:46
Peer-Review Started
2019-03-14 08:30
To Make the First Decision
2019-04-30 10:45
Return for Revision
2019-05-05 04:33
Revised
2019-05-09 01:37
Second Decision
2019-05-30 08:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-01 13:17
Articles in Press
2019-06-01 13:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-06-10 03:21
Typeset the Manuscript
2019-07-13 11:42
Publish the Manuscript Online
2019-07-14 11:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Identification of differentially-expressed genes regulated by methylation in colon cancer based on bioinformatics analysis
Manuscript Source Unsolicited Manuscript
All Author List Yu Liang, Cheng Zhang and Dong-Qiu Dai
ORCID
Author(s) ORCID Number
Yu Liang http://orcid.org/0000-0001-9136-7139
Cheng Zhang http://orcid.org/0000-0001-5317-8775
Dong-Qiu Dai http://orcid.org/0000-0002-1154-3276
Funding Agency and Grant Number
Corresponding author Dong-Qiu Dai, PhD, Chief Doctor, Professor, Surgical Oncologist, Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital of China Medical University, 4 Chongshan Road, Shenyang 110032, Liaoning Province, China. daidq63@163.com
Keywords Colon cancer; Bioinformatics analysis; The Cancer Genome Atlas project; DNA methylation; Methylation-regulated differentially-expressed genes; Overall survival
Core Tip We acquired high-throughput data from The Cancer Genome Atlas database and identified five up-regulated and 81 down-regulated Methylation-regulated differentially-expressed gene (MeDEGs). Then, we performed gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses to clarify the function of MeDEGs. Furthermore, methylation status and expression of glial cell-derived neurotrophic factor and reelin were found to be associated with overall survival. Our study revealed that methylation is critical in colon cancer development and the prognosis-related MeDEGs are worth exploring further.
Publish Date 2019-07-14 11:25
Citation Liang Y, Zhang C, Dai DQ. Identification of differentially-expressed genes regulated by methylation in colon cancer based on bioinformatics analysis. World J Gastroenterol 2019; 25(26): 3392-3407
Url https://www.wjgnet.com/1007-9327/full/v25/i26/3392.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i26.3392
Full Article (PDF) WJG-25-3392.pdf
Full Article (Word) WJG-25-3392.docx
Manuscript File 47414-Review_Edited.docx
Answering Reviewers 47414-Answering reviewers.pdf
Audio Core Tip 47414-Audio core tip.mp3
Biostatistics Review Certificate 47414-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47414-Conflict-of-interest statement.pdf
Copyright License Agreement 47414-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 47414-Language certificate.pdf
Peer-review Report 47414-Peer-review(s).pdf
Scientific Misconduct Check 47414-Scientific misconduct check.pdf
Scientific Editor Work List 47414-Scientific editor work list.pdf