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Articles Published Processes
7/14/2019 11:25:18 AM | Browse: 873 | Download: 1784
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Received |
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2019-03-14 00:46 |
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Peer-Review Started |
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2019-03-14 08:30 |
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To Make the First Decision |
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2019-04-30 10:45 |
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Return for Revision |
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2019-05-05 04:33 |
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Revised |
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2019-05-09 01:37 |
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Second Decision |
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2019-05-30 08:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-06-01 13:17 |
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Articles in Press |
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2019-06-01 13:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-06-10 03:21 |
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Typeset the Manuscript |
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2019-07-13 11:42 |
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Publish the Manuscript Online |
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2019-07-14 11:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of differentially-expressed genes regulated by methylation in colon cancer based on bioinformatics analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Liang, Cheng Zhang and Dong-Qiu Dai |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dong-Qiu Dai, PhD, Chief Doctor, Professor, Surgical Oncologist, Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital of China Medical University, 4 Chongshan Road, Shenyang 110032, Liaoning Province, China. daidq63@163.com |
| Key Words |
Colon cancer; Bioinformatics analysis; The Cancer Genome Atlas project; DNA methylation; Methylation-regulated differentially-expressed genes; Overall survival |
| Core Tip |
We acquired high-throughput data from The Cancer Genome Atlas database and identified five up-regulated and 81 down-regulated Methylation-regulated differentially-expressed gene (MeDEGs). Then, we performed gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses to clarify the function of MeDEGs. Furthermore, methylation status and expression of glial cell-derived neurotrophic factor and reelin were found to be associated with overall survival. Our study revealed that methylation is critical in colon cancer development and the prognosis-related MeDEGs are worth exploring further. |
| Publish Date |
2019-07-14 11:25 |
| Citation |
Liang Y, Zhang C, Dai DQ. Identification of differentially-expressed genes regulated by methylation in colon cancer based on bioinformatics analysis. World J Gastroenterol 2019; 25(26): 3392-3407 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i26/3392.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i26.3392 |
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