Publication Name	World Journal of Hepatology
Manuscript ID	47470
Country	Japan

Received	2019-03-20 00:51
Peer-Review Started	2019-03-20 09:42
To Make the First Decision	2019-04-17 07:33
Return for Revision	2019-04-23 01:06
Revised	2019-05-20 21:25
Second Decision	2019-06-20 06:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-27 17:24
Articles in Press	2019-06-27 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-07-26 05:58
Publish the Manuscript Online	2019-07-26 11:08

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Wilson disease developing osteoarthritic pain in severe acute liver failure: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Kido, Shirou Matsumoto, Keishin Sugawara and Kimotoshi Nakamura
ORCID	Author(s) ORCID Number Jun Kido http://orcid.org/0000-0003-1328-6696 Shirou Matsumoto http://orcid.org/0000-0003-1986-0951 Keishin Sugawara http://orcid.org/0000-0002-1345-6459 Kimotoshi Nakamura http://orcid.org/0000-0001-6659-4145
Funding Agency and Grant Number
Corresponding Author	Jun Kido, MD, PhD, Assistant Professor, Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. kidojun@kuh.kumamoto-u.ac.jp
Key Words	Acute liver failure; New Wilson Index; Osteoarthritis; Wilson disease; Case report;
Core Tip	We present an 11-year-old boy with Wilson disease (WD) who developed osteoarthritis symptoms and acute liver failure, with a New Wilson Index Score (NWIS) of 12. His liver cirrhosis improved, leading to almost normal liver function and liver imaging results, one year after receiving combination therapy with Zn and a chelator. Patients with WD with a NWIS > 11 may be able to survive with treatment with Zn and chelators, without liver transplantation, in cases wherein they present with mild hyperbilirubinemia and stage ≤ II hepatic encephalopathy. Symptoms of associated osteoarthritis may also improve with long-term Zn and chelator therapy.
Publish Date	2019-07-26 11:08
Citation	Kido J, Matsumoto S, Sugawara K, Nakamura K. Wilson disease developing osteoarthritic pain in severe acute liver failure: A case report. World J Hepatol 2019; 11(7): 607-612
URL	https://www.wjgnet.com/1948-5182/full/v11/i7/607.htm
DOI	https://dx.doi.org/10.4254/wjh.v11.i7.607

Full Article (PDF)	WJH-11-607.pdf
Full Article (Word)	WJH-11-607.docx
Manuscript File	47470-Review.docx
Answering Reviewers	47470-Answering reviewers.pdf
Audio Core Tip	47470-Audio core tip.WAV
Conflict-of-Interest Disclosure Form	47470-Conflict-of-interest statement.pdf
Copyright License Agreement	47470-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	47470-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	47470-Language certificate.pdf
Peer-review Report	47470-Peer-review(s).pdf
Scientific Misconduct Check	47470-Scientific misconduct check.pdf
Scientific Editor Work List	47470-Scientific editor work list.pdf