Publication Name	World Journal of Hepatology
Manuscript ID	47485
Country	Italy

Received	2019-03-15 03:11
Peer-Review Started	2019-03-15 06:29
To Make the First Decision	2019-04-17 02:26
Return for Revision	2019-04-22 10:21
Revised	2019-05-16 14:07
Second Decision	2019-05-17 07:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-05-21 06:12
Articles in Press	2019-05-21 06:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-05-24 19:09
Typeset the Manuscript	2019-06-27 08:22
Publish the Manuscript Online	2019-06-27 10:40

ISSN	1948-5182 (online)
Open Access
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Daniela Campion, Ilaria Giovo, Paola Ponzo, Giorgio M Saracco, Federico Balzola and Carlo Alessandria
ORCID	Author(s) ORCID Number Daniela Campion http://orcid.org/0000-0001-8782-1124 Ilaria Giovo http://orcid.org/0000-0002-6368-2964 Paola Ponzo http://orcid.org/0000-0002-1959-1379 Giorgio M Saracco http://orcid.org/0000-0001-5310-4143 Federico Balzola http://orcid.org/0000-0001-5989-9303 Carlo Alessandria http://orcid.org/0000-0001-5468-694X
Funding Agency and Grant Number
Corresponding Author	Carlo Alessandria, MD, Doctor, Doctor, Division of Gastroenterology and Hepatology, Città della Salute e della Scienza di Torino Hospital, University of Turin, C.so Bramante 88, Turin 10126, Italy. carloalessandria@libero.it
Key Words	Cirrhosis; Hepatic encephalopathy; Diet therapy; Gut microbiota; Leaky gut; Hyperammonemia; Prebiotics; Probiotics; Gluten-casein free diet; Gut microbiota transplantation
Core Tip	Hepatic encephalopathy (HE) is a serious complication of cirrhosis resulting from a multifactorial impairment of gut-liver-brain axis functioning. Multiple interrelated factors (e.g., intestinal hyperpermeability, dysbiosis, hyperammonemia, inflammation) cooperate in its development. “Gut-centric” therapies, including non-absorbable disaccharides, antibiotics, prebiotics, probiotics, and fecal microbiota transplantation have been successfully employed to manage HE: pertinent current knowledge will be reviewed. Furthermore, the utility of dietary modifications in this context is increasingly recognized, thus opening a new promising research path. This review sheds light on dietary therapeutic strategies for HE, exploring how they can target the mechanisms underlying gut-liver-brain axis dysregulation.
Publish Date	2019-06-27 10:40
Citation	Campion D, Giovo I, Ponzo P, Saracco GM, Balzola F, Alessandria C. Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis. World J Hepatol 2019; 11(6): 489-512
URL	https://www.wjgnet.com/1948-5182/full/v11/i6/489.htm
DOI	https://dx.doi.org/10.4254/wjh.v11.i6.489

Full Article (PDF)	WJH-11-489.pdf
Full Article (Word)	WJH-11-489.docx
Manuscript File	FP6864_de5_CE1RUSHMS-2.docx
Answering Reviewers	47485-Answering reviewers.pdf
Audio Core Tip	47485-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	47485-Conflict-of-interest statement.pdf
Copyright License Agreement	47485-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	47485-Language certificate.pdf
Peer-review Report	47485-Peer-review(s).pdf
Scientific Misconduct Check	47485-Scientific misconduct check.pdf
Scientific Editor Work List	47485-Scientific editor work list.pdf
CrossCheck Report	47485-CrossCheck Report.pdf