Publication Name	World Journal of Gastroenterology
Manuscript ID	4754
Country	China

Received	2013-07-21 13:05
Peer-Review Started	2013-07-22 13:37
First Decision by Editorial Office Director
Return for Revision	2013-08-24 16:30
Revised	2013-09-05 23:40
Publication Fee Transferred
Second Decision by Editor	2013-09-29 11:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-09-29 22:00
Articles in Press
Edit the Manuscript by Language Editor	2013-10-15 14:19
Typeset the Manuscript	2013-11-26 10:15
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Autobiography
Article Title	PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation
Manuscript Source	Invited Manuscript
All Author List	Xing-Wei Xu, Bo-Wen Ding, Chuan-Rong Zhu, Wu Ji and Jie-Shou Li
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Jiangsu Province, China BK2008237
Corresponding Author	Wu Ji, MD, Professor, Jinling Hospital, Research Institute of General Surgery, Nanjing University, School of Medicine, No.305, East Zhongshan Road, Xuanwu District, Nanjing 210002, Jiangsu Province, China. jiwusky@126.com
Key Words	Immune tolerance; Intestinal transplantation; Tolerance; PU.1; Dendritic cell
Core Tip	The inhibition of dendritic cells (DCs) maturation can promote their tolerogenicity in transplantation. PU.1 is a newly discovered transcription factor which is required for the regulation of dendritic cell maturation in all DCs subsets. We silenced the PU.1 gene using siRNA and showed, for the first time, that PU.1-silenced DCs had immune tolerance. This may be a new strategy to prevent graft rejection following intestinal transplantation.
Publish Date	2013-12-18 09:53
Citation	Xu XW, Ding BW, Zhu CR, J i W, Li JS. PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation. World J Gastroenterol 2013; 19(43): 7766-7771
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7766.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7766

Full Article (PDF)	WJG-19-7766.pdf
Manuscript File	4754-Review.doc
Answering Reviewers	4754-Answering reviewers.pdf
Copyright License Agreement	4754-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4754-Language certificate.PDF
Peer-review Report	4754-Peer review(s).pdf
Scientific Editor Work List	4754-Scientific editor work list.doc