Publication Name	World Journal of Gastroenterology
Manuscript ID	47558
Country	Germany

Received	2019-03-18 04:04
Peer-Review Started	2019-03-19 00:47
To Make the First Decision	2019-05-14 01:15
Return for Revision	2019-05-15 01:16
Revised	2019-05-21 18:23
Second Decision	2019-06-26 10:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-07-03 01:13
Articles in Press	2019-07-03 01:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-07-10 20:50
Typeset the Manuscript	2019-08-06 02:30
Publish the Manuscript Online	2019-08-07 07:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Immunotherapy in colorectal cancer: Available clinical evidence, challenges and novel approaches
Manuscript Source	Invited Manuscript
All Author List	Joseph Tintelnot and Alexander Stein
ORCID	Author(s) ORCID Number Joseph Tintelnot http://orcid.org/0000-0003-4619-9433 Alexander Stein http://orcid.org/0000-0002-9768-0086
Funding Agency and Grant Number
Corresponding Author	Alexander Stein, MD, Assistant Professor, Department of Internal Medicine II (Oncology Center), University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany. a.stein@uke.de
Key Words	Immunotherapy; Combination; Colorectal cancer; Metastatic; Adjuvant;
Core Tip	Colorectal cancer is not responsive to single agent programmed death 1/ligand 1 or cytotoxic T lymphocyte-associated antigen-4 inhibitors, beside the subset of mismatch repair deficient or microsatellite instable tumors. Thus, a variety of combination approaches with chemotherapy, targeted therapy, toll like receptor agonists, local ablation or oncolytic viruses are currently evaluated to enhance immunogenicity of mismatch repair proficient colorectal cancers. Here we review current clinical evidence, challenges and novel approaches in ongoing clinical programs.
Publish Date	2019-08-07 07:09
Citation	Tintelnot J, Stein A. Immunotherapy in colorectal cancer: Available clinical evidence, challenges and novel approaches. World J Gastroenterol 2019; 25(29): 3920-3928
URL	https://www.wjgnet.com/1007-9327/full/v25/i29/3920.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i29.3920

Full Article (PDF)	WJG-25-3920.pdf
Full Article (Word)	WJG-25-3920.docx
Manuscript File	FP6909_de16_CE1MS_edit2-2.docx
Answering Reviewers	47558-Answering reviewers.pdf
Audio Core Tip	47558-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	47558-Conflict-of-interest statement.pdf
Copyright License Agreement	47558-Copyright license agreement.pdf
Peer-review Report	47558-Peer-review(s).pdf
Scientific Misconduct Check	47558-Scientific misconduct check.pdf
Scientific Editor Work List	47558-Scientific editor work list.pdf
CrossCheck Report	47558-CrossCheck Report.pdf