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Articles Published Processes
8/28/2019 12:23:27 PM | Browse: 1273 | Download: 2483
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Received |
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2019-03-28 02:21 |
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Peer-Review Started |
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2019-03-28 05:47 |
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First Decision by Editorial Office Director |
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2019-04-16 14:03 |
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Return for Revision |
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2019-04-17 04:13 |
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Revised |
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2019-07-14 03:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-07-19 09:07 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-07-19 16:27 |
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Articles in Press |
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2019-07-19 16:27 |
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Edit the Manuscript by Language Editor |
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2019-08-16 16:52 |
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Typeset the Manuscript |
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2019-08-28 07:51 |
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Publish the Manuscript Online |
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2019-08-28 12:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ran-Xu Zhu, Alfred Sze Lok Cheng, Henry Lik Yuen Chan, Dong-Ye Yang and Wai-Kay Seto |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81702777 |
| Natural Science Foundation of Guangdong Province |
2015A030310053 |
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| Corresponding Author |
Ran-Xu Zhu, MD, PhD, Doctor, Doctor, Department of Gastroenterology and Hepatology, The University of Hong Kong–Shenzhen Hospital, No. 1 Haiyuan Road, Futian District, Shenzhen 518053, Guangdong Province, China. zhurx@hku-szh.org |
| Key Words |
Growth arrest-specific gene 2; Cell cycle; Apoptosis; Hepatocellular carcinoma; p53-dependent signaling pathway; |
| Core Tip |
This study elucidated the function and mechanism of growth arrest-specific gene 2 (GAS2) in hepatocellular carcinoma (HCC) progression. By overexpression and knockdown approaches, we detected that GAS2 acted to inhibit the proliferation of HCC with wild-type p53. The effect of GAS2 on cell cycle and apoptosis was investigated by flow cytometry, Annexin V apoptosis and western blot assay, respectively. GAS2 suppressed HCC proliferation by deregulating cell cycle and P53-dependent apoptosis pathway. Thus, GAS2 is expected to be a promising anti-oncogene and potential therapeutic target in HCC with wild-type p53. |
| Publish Date |
2019-08-28 12:23 |
| Citation |
Zhu RX, Cheng ASL, Chan HLY, Yang DY, Seto WK. Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis. World J Gastroenterol 2019; 25(32): 4715-4726 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i32/4715.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i32.4715 |
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