Publication Name	World Journal of Gastroenterology
Manuscript ID	4762
Country	Greece

Received	2013-07-24 08:31
Peer-Review Started	2013-07-24 12:11
To Make the First Decision	2013-12-04 08:55
Return for Revision	2013-12-04 19:23
Revised	2014-02-22 01:32
Second Decision	2014-04-16 11:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-16 12:07
Articles in Press	2014-05-23 10:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-24 09:56
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Letter to the Editor
Article Title	E2F transcription factors and digestive system malignancies: How much do we know?
Manuscript Source	Invited Manuscript
All Author List	Konstantinos Evangelou, Sophia Havaki and Athanassios Kotsinas
Funding Agency and Grant Number
Corresponding Author	Athanassios Kotsinas, BSc, PhD, Laboratory Histology-Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str, 11527 Goudi, Athens, Greece. akotsin@med.uoa.gr
Key Words	E2F; Hepatocellular carcinoma; Pancreatic ductal adenocarcinoma; Gastrointestinal tract; Digestive system; p53; p73; Cancer; Apoptosis; Proliferation
Core Tip	The roles of the E2F transcription factors can vary significantly in malignancies of the digestive system, often dictating different outcomes in separate compartments of the gastrointestinal tract. Knowledge of the molecular status of the regulatory networks that E2Fs participate in is imperative to define their role. Therefore the use of proper molecular analysis to investigate these networks, complemented also by functional analysis in cellular and animal models, is essential. All in all, such an approach can define chronologically and provide a wider and more accurate view on the exact roles that E2Fs may exhibit in the development of specific digestive system malignancies.
Publish Date	2014-08-07 10:34
Citation	Evangelou K, Havaki S, Kotsinas A. E2F transcription factors and digestive system malignancies: How much do we know? World J Gastroenterol 2014; 20(29): 10212-10216
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/10212.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.10212

Full Article (PDF)	WJG-20-10212.pdf
Full Article (Word)	WJG-20-10212.doc
Manuscript File	4762-Review.doc
Answering Reviewers	4762-Answering reviewers.pdf
Copyright License Agreement	4762-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4762-Language certificate.pdf
Peer-review Report	4762-Peer review.pdf
Scientific Editor Work List	4762-Scientific editor work list.doc