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Articles Published Processes
8/7/2019 7:09:17 AM | Browse: 766 | Download: 1392
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Received |
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2019-03-26 02:20 |
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Peer-Review Started |
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2019-03-26 04:55 |
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To Make the First Decision |
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2019-05-27 00:35 |
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Return for Revision |
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2019-05-31 01:50 |
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Revised |
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2019-06-13 15:31 |
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Second Decision |
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2019-07-05 10:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-05 23:48 |
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Articles in Press |
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2019-07-05 23:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-07-15 03:35 |
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Typeset the Manuscript |
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2019-08-05 08:32 |
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Publish the Manuscript Online |
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2019-08-07 07:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Ying Xia, Li Gao, Er-Hei Dai, Dan Chen, Er-Fu Xie, Li Yang, Shi-Chang Zhang, Bing-Feng Zhang, Jian Xu and Shi-Yang Pan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81672100 |
| National Natural Science Foundation of China |
81371894 |
| Key Laboratory for Laboratory Medicine of Jiangsu Province of China |
ZDXKB2016005 |
| Jiangsu Provincial Commission of Health and Family Planning |
H201609 |
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| Corresponding Author |
Shi-Yang Pan, MD, Professor, Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Guangzhou Road No. 300, Nanjing 210029, Jiangsu Province, China. sypan@njmu.edu.cn |
| Key Words |
Liquid biopsy; plasma DNA; Hepatitis B; Alanine aminotransferase; Duplex real-time quantitative polymerase chain reaction; |
| Core Tip |
Our study quantified cell free DNA combined with other serum biomarker as a liquid biopsy-based method to assess liver injury in hepatitis B patients. A cohort of 663 subjects including 313 hepatitis B patients and 350 healthy controls were enrolled. The ultrasound-guided liver biopsies followed by histopathological assessments were performed for the 263 chronic hepatitis B patients to determine the degree of liver injury. Cell-free DNA was quantified using a novel duplex real-time polymerase chain reaction assay. Our results demonstrated that the combination of plasma DNA, serum alanine aminotransferase and bilirubin could be a candidate liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients. |
| Publish Date |
2019-08-07 07:09 |
| Citation |
Xia WY, Gao L, Dai EH, Chen D, Xie EF, Yang L, Zhang SC, Zhang BF, Xu J, Pan SY. Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients. World J Gastroenterol 2019; 25(29): 3985-3995 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i29/3985.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i29.3985 |
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